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All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy.

Publication ,  Journal Article
Yan, Y; Li, Z; Xu, X; Chen, C; Wei, W; Fan, M; Chen, X; Li, JJ; Wang, Y; Huang, J
Published in: BMC Complement Altern Med
March 31, 2016

BACKGROUND: Radiotherapy is of critical importance in the treatment of breast cancer. However, not all patients derive therapeutic benefit and some breast cancers are resistant to the treatment, and are thus evidenced with prospective distant metastatic spread and local recurrence. In this study, we investigated the potential therapeutic effects of all-trans retinoic acid (ATRA) on radiation-resistant breast cancer cells and the associated invasiveness. METHODS: The MCF7/C6 cells with gained radiation resistance after a long term treatment with fractionated ionizing radiation were derived from human breast cancer MCF7 cell line, and are enriched with cells expressing putative breast cancer stem cell biomarker CD44(+)/CD24(-/low)/ALDH(+). The enhanced invasiveness and the acquired resistances to chemotherapeutic treatments of MCF7/C6 cells were measured, and potential effects of all-trans retinoic acid (ATRA) on the induction of differentiation, invasion and migration, and on the sensitivities to chemotherapies in MCF7/C6 cells were investigated. RESULTS: MCF7/C6 cells are with enrichment of cancer stem-cell like cells with positive staining of CD44(+)/CD24(-/low), OCT3/4 and NANOG. MCF7/C6 cells showed an increased tumoregensis potential and enhanced aggressiveness of invasion and migration. Treatment with ATRA induces the differentiation in MCF7/C6 cells, resulting in reduced invasiveness and migration, and increased sensitivity to Epirubincin treatment. CONCLUSION: Our study suggests a potential clinic impact for ATRA as a chemotherapeutic agent for treatment of therapy-resistant breast cancer especially for the metastatic lesions. The study also provides a rationale for ATRA as a sensitizer of Epirubincin, a first-line treatment option for breast cancer patients.

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Published In

BMC Complement Altern Med

DOI

EISSN

1472-6882

Publication Date

March 31, 2016

Volume

16

Start / End Page

113

Location

England

Related Subject Headings

  • Tretinoin
  • Radiation Tolerance
  • Neoplastic Stem Cells
  • Neoplasm Invasiveness
  • Hyaluronan Receptors
  • Humans
  • Female
  • Complementary & Alternative Medicine
  • Combined Modality Therapy
  • Cell Line, Tumor
 

Citation

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Chicago
ICMJE
MLA
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Yan, Y., Li, Z., Xu, X., Chen, C., Wei, W., Fan, M., … Huang, J. (2016). All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. BMC Complement Altern Med, 16, 113. https://doi.org/10.1186/s12906-016-1088-y
Yan, Yunwen, Zhen Li, Xiang Xu, Clark Chen, Wei Wei, Ming Fan, Xufeng Chen, Jian Jian Li, Yuan Wang, and Jiaoti Huang. “All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy.BMC Complement Altern Med 16 (March 31, 2016): 113. https://doi.org/10.1186/s12906-016-1088-y.
Yan Y, Li Z, Xu X, Chen C, Wei W, Fan M, et al. All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. BMC Complement Altern Med. 2016 Mar 31;16:113.
Yan, Yunwen, et al. “All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy.BMC Complement Altern Med, vol. 16, Mar. 2016, p. 113. Pubmed, doi:10.1186/s12906-016-1088-y.
Yan Y, Li Z, Xu X, Chen C, Wei W, Fan M, Chen X, Li JJ, Wang Y, Huang J. All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. BMC Complement Altern Med. 2016 Mar 31;16:113.
Journal cover image

Published In

BMC Complement Altern Med

DOI

EISSN

1472-6882

Publication Date

March 31, 2016

Volume

16

Start / End Page

113

Location

England

Related Subject Headings

  • Tretinoin
  • Radiation Tolerance
  • Neoplastic Stem Cells
  • Neoplasm Invasiveness
  • Hyaluronan Receptors
  • Humans
  • Female
  • Complementary & Alternative Medicine
  • Combined Modality Therapy
  • Cell Line, Tumor