Use of Direct Oral Anticoagulants in Special Populations.
Publication
, Journal Article
Li, A; Lopes, RD; Garcia, DA
Published in: Hematol Oncol Clin North Am
October 2016
Direct oral anticoagulants (DOACs) have been approved for the treatment of venous thromboembolism and atrial fibrillation based on randomized controlled trials (RCTs) of direct comparisons with vitamin K antagonists. Despite having more than 100,000 patients enrolled, safety and efficacy are debated in selected populations. Although DOACs are reviewed as a class of anticoagulant, pharmacokinetic differences exist such that different medications may be beneficial in distinct clinical settings. Synthesizing available evidence based on phase III RCTs, post hoc subgroup analyses, and pooled metaanalyses, this review provides an overview of DOACs and scrutinizes individual differences in their applications for the special populations.
Duke Scholars
Published In
Hematol Oncol Clin North Am
DOI
EISSN
1558-1977
Publication Date
October 2016
Volume
30
Issue
5
Start / End Page
1053 / 1071
Location
United States
Related Subject Headings
- Vitamin K
- Venous Thromboembolism
- Randomized Controlled Trials as Topic
- Oncology & Carcinogenesis
- Humans
- Clinical Trials, Phase III as Topic
- Atrial Fibrillation
- Anticoagulants
- Administration, Oral
- 3201 Cardiovascular medicine and haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, A., Lopes, R. D., & Garcia, D. A. (2016). Use of Direct Oral Anticoagulants in Special Populations. Hematol Oncol Clin North Am, 30(5), 1053–1071. https://doi.org/10.1016/j.hoc.2016.05.003
Li, Ang, Renato D. Lopes, and David A. Garcia. “Use of Direct Oral Anticoagulants in Special Populations.” Hematol Oncol Clin North Am 30, no. 5 (October 2016): 1053–71. https://doi.org/10.1016/j.hoc.2016.05.003.
Li A, Lopes RD, Garcia DA. Use of Direct Oral Anticoagulants in Special Populations. Hematol Oncol Clin North Am. 2016 Oct;30(5):1053–71.
Li, Ang, et al. “Use of Direct Oral Anticoagulants in Special Populations.” Hematol Oncol Clin North Am, vol. 30, no. 5, Oct. 2016, pp. 1053–71. Pubmed, doi:10.1016/j.hoc.2016.05.003.
Li A, Lopes RD, Garcia DA. Use of Direct Oral Anticoagulants in Special Populations. Hematol Oncol Clin North Am. 2016 Oct;30(5):1053–1071.
Published In
Hematol Oncol Clin North Am
DOI
EISSN
1558-1977
Publication Date
October 2016
Volume
30
Issue
5
Start / End Page
1053 / 1071
Location
United States
Related Subject Headings
- Vitamin K
- Venous Thromboembolism
- Randomized Controlled Trials as Topic
- Oncology & Carcinogenesis
- Humans
- Clinical Trials, Phase III as Topic
- Atrial Fibrillation
- Anticoagulants
- Administration, Oral
- 3201 Cardiovascular medicine and haematology