Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

The association between cognitive function and subsequent depression: a systematic review and meta-analysis.

Publication ,  Journal Article
Scult, MA; Paulli, AR; Mazure, ES; Moffitt, TE; Hariri, AR; Strauman, TJ
Published in: Psychol Med
January 2017

Despite a growing interest in understanding the cognitive deficits associated with major depressive disorder (MDD), it is largely unknown whether such deficits exist before disorder onset or how they might influence the severity of subsequent illness. The purpose of the present study was to conduct a systematic review and meta-analysis of longitudinal datasets to determine whether cognitive function acts as a predictor of later MDD diagnosis or change in depression symptoms. Eligible studies included longitudinal designs with baseline measures of cognitive functioning, and later unipolar MDD diagnosis or symptom assessment. The systematic review identified 29 publications, representing 34 unique samples, and 121 749 participants, that met the inclusion/exclusion criteria. Quantitative meta-analysis demonstrated that higher cognitive function was associated with decreased levels of subsequent depression (r = -0.088, 95% confidence interval. -0.121 to -0.054, p < 0.001). However, sensitivity analyses revealed that this association is likely driven by concurrent depression symptoms at the time of cognitive assessment. Our review and meta-analysis indicate that the association between lower cognitive function and later depression is confounded by the presence of contemporaneous depression symptoms at the time of cognitive assessment. Thus, cognitive deficits predicting MDD likely represent deleterious effects of subclinical depression symptoms on performance rather than premorbid risk factors for disorder.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Psychol Med

DOI

EISSN

1469-8978

Publication Date

January 2017

Volume

47

Issue

1

Start / End Page

1 / 17

Location

England

Related Subject Headings

  • Psychiatry
  • Prodromal Symptoms
  • Humans
  • Depressive Disorder, Major
  • Cognitive Dysfunction
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Scult, M. A., Paulli, A. R., Mazure, E. S., Moffitt, T. E., Hariri, A. R., & Strauman, T. J. (2017). The association between cognitive function and subsequent depression: a systematic review and meta-analysis. Psychol Med, 47(1), 1–17. https://doi.org/10.1017/S0033291716002075
Scult, M. A., A. R. Paulli, E. S. Mazure, T. E. Moffitt, A. R. Hariri, and T. J. Strauman. “The association between cognitive function and subsequent depression: a systematic review and meta-analysis.Psychol Med 47, no. 1 (January 2017): 1–17. https://doi.org/10.1017/S0033291716002075.
Scult MA, Paulli AR, Mazure ES, Moffitt TE, Hariri AR, Strauman TJ. The association between cognitive function and subsequent depression: a systematic review and meta-analysis. Psychol Med. 2017 Jan;47(1):1–17.
Scult, M. A., et al. “The association between cognitive function and subsequent depression: a systematic review and meta-analysis.Psychol Med, vol. 47, no. 1, Jan. 2017, pp. 1–17. Pubmed, doi:10.1017/S0033291716002075.
Scult MA, Paulli AR, Mazure ES, Moffitt TE, Hariri AR, Strauman TJ. The association between cognitive function and subsequent depression: a systematic review and meta-analysis. Psychol Med. 2017 Jan;47(1):1–17.
Journal cover image

Published In

Psychol Med

DOI

EISSN

1469-8978

Publication Date

January 2017

Volume

47

Issue

1

Start / End Page

1 / 17

Location

England

Related Subject Headings

  • Psychiatry
  • Prodromal Symptoms
  • Humans
  • Depressive Disorder, Major
  • Cognitive Dysfunction
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services