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Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study.

Publication ,  Journal Article
McClelland, AC; Gomes, WA; Shinnar, S; Hesdorffer, DC; Bagiella, E; Lewis, DV; Bello, JA; Chan, S; MacFall, J; Chen, M; Pellock, JM; Frank, LM ...
Published in: AJNR Am J Neuroradiol
December 2016

BACKGROUND AND PURPOSE: The pathogenesis of febrile status epilepticus is poorly understood, but prior studies have suggested an association with temporal lobe abnormalities, including hippocampal malrotation. We used a quantitative morphometric method to assess the association between temporal lobe morphology and febrile status epilepticus. MATERIALS AND METHODS: Brain MR imaging was performed in children presenting with febrile status epilepticus and control subjects as part of the Consequences of Prolonged Febrile Seizures in Childhood study. Medial temporal lobe morphologic parameters were measured manually, including the distance of the hippocampus from the midline, hippocampal height:width ratio, hippocampal angle, collateral sulcus angle, and width of the temporal horn. RESULTS: Temporal lobe morphologic parameters were correlated with the presence of visual hippocampal malrotation; the strongest association was with left temporal horn width (P < .001; adjusted OR, 10.59). Multiple morphologic parameters correlated with febrile status epilepticus, encompassing both the right and left sides. This association was statistically strongest in the right temporal lobe, whereas hippocampal malrotation was almost exclusively left-sided in this cohort. The association between temporal lobe measurements and febrile status epilepticus persisted when the analysis was restricted to cases with visually normal imaging findings without hippocampal malrotation or other visually apparent abnormalities. CONCLUSIONS: Several component morphologic features of hippocampal malrotation are independently associated with febrile status epilepticus, even when complete hippocampal malrotation is absent. Unexpectedly, this association predominantly involves the right temporal lobe. These findings suggest that a spectrum of bilateral temporal lobe anomalies are associated with febrile status epilepticus in children. Hippocampal malrotation may represent a visually apparent subset of this spectrum.

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Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

December 2016

Volume

37

Issue

12

Start / End Page

2356 / 2362

Location

United States

Related Subject Headings

  • Temporal Lobe
  • Status Epilepticus
  • Seizures, Febrile
  • Nuclear Medicine & Medical Imaging
  • Neuroimaging
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McClelland, A. C., Gomes, W. A., Shinnar, S., Hesdorffer, D. C., Bagiella, E., Lewis, D. V., … FEBSTAT Study Team, . (2016). Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study. AJNR Am J Neuroradiol, 37(12), 2356–2362. https://doi.org/10.3174/ajnr.A4919
McClelland, A. C., W. A. Gomes, S. Shinnar, D. C. Hesdorffer, E. Bagiella, D. V. Lewis, J. A. Bello, et al. “Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study.AJNR Am J Neuroradiol 37, no. 12 (December 2016): 2356–62. https://doi.org/10.3174/ajnr.A4919.
McClelland AC, Gomes WA, Shinnar S, Hesdorffer DC, Bagiella E, Lewis DV, et al. Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study. AJNR Am J Neuroradiol. 2016 Dec;37(12):2356–62.
McClelland, A. C., et al. “Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study.AJNR Am J Neuroradiol, vol. 37, no. 12, Dec. 2016, pp. 2356–62. Pubmed, doi:10.3174/ajnr.A4919.
McClelland AC, Gomes WA, Shinnar S, Hesdorffer DC, Bagiella E, Lewis DV, Bello JA, Chan S, MacFall J, Chen M, Pellock JM, Nordli DR, Frank LM, Moshé SL, Shinnar RC, Sun S, FEBSTAT Study Team. Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study. AJNR Am J Neuroradiol. 2016 Dec;37(12):2356–2362.

Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

December 2016

Volume

37

Issue

12

Start / End Page

2356 / 2362

Location

United States

Related Subject Headings

  • Temporal Lobe
  • Status Epilepticus
  • Seizures, Febrile
  • Nuclear Medicine & Medical Imaging
  • Neuroimaging
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female