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Osteopontin has a protective role in prostate tumor development in mice.

Publication ,  Journal Article
Danzaki, K; Kanayama, M; Alcazar, O; Shinohara, ML
Published in: Eur J Immunol
November 2016

Osteopontin (OPN) is a protein, generally considered to play a pro-tumorigenic role, whereas several reports have demonstrated the anti-tumorigenic function of OPN during tumor development. These opposing anti- and pro-tumorigenic functions are not fully understood. Here, we report that host-derived OPN plays an anti-tumorigenic role in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model and a TRAMP tumor transplant model. Tumor suppression mediated by OPN in Rag2-/- mice suggests that OPN is dispensable in the adaptive immune response. We found that host-derived OPN enhanced infiltration of natural killer (NK) cells into TRAMP tumors. The requirement of OPN in NK cell migration towards TRAMP cells was confirmed by an ex vivo cell migration assay. In contrast to TRAMP cells, in vivo B16 tumor development was not inhibited by OPN, and B16 tumors did not show OPN-mediated cell recruitment. It is possible that low levels of chemokine expression by B16 cells do not allow OPN to enhance immune cell recruitment. In addition to demonstrating the anti-tumorigenic role of OPN in TRAMP tumor development, this study also suggests that the contribution of OPN to tumor development depends on the type of tumor as well as the source and isoform of OPN.

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Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

November 2016

Volume

46

Issue

11

Start / End Page

2669 / 2678

Location

Germany

Related Subject Headings

  • Signal Transduction
  • Prostatic Neoplasms
  • Osteopontin
  • Neoplasm Transplantation
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Melanoma, Experimental
  • Male
  • Killer Cells, Natural
 

Citation

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Danzaki, K., Kanayama, M., Alcazar, O., & Shinohara, M. L. (2016). Osteopontin has a protective role in prostate tumor development in mice. Eur J Immunol, 46(11), 2669–2678. https://doi.org/10.1002/eji.201646391
Danzaki, Keiko, Masashi Kanayama, Oscar Alcazar, and Mari L. Shinohara. “Osteopontin has a protective role in prostate tumor development in mice.Eur J Immunol 46, no. 11 (November 2016): 2669–78. https://doi.org/10.1002/eji.201646391.
Danzaki K, Kanayama M, Alcazar O, Shinohara ML. Osteopontin has a protective role in prostate tumor development in mice. Eur J Immunol. 2016 Nov;46(11):2669–78.
Danzaki, Keiko, et al. “Osteopontin has a protective role in prostate tumor development in mice.Eur J Immunol, vol. 46, no. 11, Nov. 2016, pp. 2669–78. Pubmed, doi:10.1002/eji.201646391.
Danzaki K, Kanayama M, Alcazar O, Shinohara ML. Osteopontin has a protective role in prostate tumor development in mice. Eur J Immunol. 2016 Nov;46(11):2669–2678.
Journal cover image

Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

November 2016

Volume

46

Issue

11

Start / End Page

2669 / 2678

Location

Germany

Related Subject Headings

  • Signal Transduction
  • Prostatic Neoplasms
  • Osteopontin
  • Neoplasm Transplantation
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Melanoma, Experimental
  • Male
  • Killer Cells, Natural