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Clinical perspectives on reperfusion injury in acute myocardial infarction.

Publication ,  Journal Article
Bainey, KR; Armstrong, PW
Published in: Am Heart J
May 2014

Prompt reperfusion therapy in acute myocardial infarction enhances clinical outcome. However, reperfusion itself may contribute to myocardial cell death. The current review outlines the multifocal mechanisms of reperfusion injury and focuses on understanding the potential role of each element and its contribution to the injury pattern inflicted upon the myocardium. We evaluate the spectrum of contemporary therapies that have been tested in an attempt to reduce myocardial injury. Finally, we explore promising innovative strategies targeting novel reperfusion injury pathways to protect ischemic myocardium during reperfusion.

Duke Scholars

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2014

Volume

167

Issue

5

Start / End Page

637 / 645

Location

United States

Related Subject Headings

  • Myocytes, Cardiac
  • Myocardial Revascularization
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Ischemic Preconditioning, Myocardial
  • Humans
  • Electrocardiography
  • Coronary Circulation
  • Cardiovascular System & Hematology
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bainey, K. R., & Armstrong, P. W. (2014). Clinical perspectives on reperfusion injury in acute myocardial infarction. Am Heart J, 167(5), 637–645. https://doi.org/10.1016/j.ahj.2014.01.015
Bainey, Kevin R., and Paul W. Armstrong. “Clinical perspectives on reperfusion injury in acute myocardial infarction.Am Heart J 167, no. 5 (May 2014): 637–45. https://doi.org/10.1016/j.ahj.2014.01.015.
Bainey KR, Armstrong PW. Clinical perspectives on reperfusion injury in acute myocardial infarction. Am Heart J. 2014 May;167(5):637–45.
Bainey, Kevin R., and Paul W. Armstrong. “Clinical perspectives on reperfusion injury in acute myocardial infarction.Am Heart J, vol. 167, no. 5, May 2014, pp. 637–45. Pubmed, doi:10.1016/j.ahj.2014.01.015.
Bainey KR, Armstrong PW. Clinical perspectives on reperfusion injury in acute myocardial infarction. Am Heart J. 2014 May;167(5):637–645.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2014

Volume

167

Issue

5

Start / End Page

637 / 645

Location

United States

Related Subject Headings

  • Myocytes, Cardiac
  • Myocardial Revascularization
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Ischemic Preconditioning, Myocardial
  • Humans
  • Electrocardiography
  • Coronary Circulation
  • Cardiovascular System & Hematology
  • Animals