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US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.

Publication ,  Journal Article
Ahmad, ZS; Andersen, RL; Andersen, LH; O'Brien, EC; Kindt, I; Shrader, P; Vasandani, C; Newman, CB; deGoma, EM; Baum, SJ; Hemphill, LC ...
Published in: J Clin Lipidol
2016

BACKGROUND: In the US familial hypercholesterolemia (FH), patients are underidentified, despite an estimated prevalence of 1:200 to 1:500. Criteria to identify FH patients include Simon Broome, Dutch Lipid Clinic Network (DLCN), or Make Early Diagnosis to Prevent Early Deaths (MEDPED). The use of these criteria in US clinical practices remains unclear. OBJECTIVE: To characterize the FH diagnostic criteria applied by US lipid specialists participating in the FH Foundation's CASCADE FH (CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia) patient registry. METHODS: We performed an observational, cross-sectional analysis of diagnostic criteria chosen for each adult patient, both overall and by baseline patient characteristics, at 15 clinical sites that had contributed data to the registry as of September 8, 2015. A sample of 1867 FH adults was analyzed. The median age at FH diagnosis was 50 years, and the median pretreatment low-density lipoprotein cholesterol (LDL-C) value was 238 mg/dL. The main outcome was the diagnostic criteria chosen. Diagnostic criteria were divided into five nonexclusive categories: "clinical diagnosis," MEDPED, Simon Broome, DLCN, and other. RESULTS: Most adults enrolled in CASCADE FH (55.0%) received a "clinical diagnosis." The most commonly used formal criteria was Simon-Broome only (21%), followed by multiple diagnostic criteria (16%), MEDPED only (7%), DLCN only (1%), and other (0.5%), P < .0001. Of the patients with only a "clinical diagnosis," 93% would have met criteria for Simon Broome, DLCN, or MEDPED based on the data available in the registry. CONCLUSIONS: Our findings demonstrate heterogeneity in the application of FH diagnostic criteria in the United States. A nationwide consensus definition may lead to better identification, earlier treatment, and ultimately CHD prevention.

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Published In

J Clin Lipidol

DOI

ISSN

1933-2874

Publication Date

2016

Volume

10

Issue

5

Start / End Page

1223 / 1229

Location

United States

Related Subject Headings

  • United States
  • Registries
  • Physicians
  • Middle Aged
  • Male
  • Hyperlipoproteinemia Type II
  • Humans
  • Female
  • Databases, Factual
  • Cross-Sectional Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ahmad, Z. S., Andersen, R. L., Andersen, L. H., O’Brien, E. C., Kindt, I., Shrader, P., … Knowles, J. W. (2016). US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry. J Clin Lipidol, 10(5), 1223–1229. https://doi.org/10.1016/j.jacl.2016.07.011
Ahmad, Zahid S., Rolf L. Andersen, Lars H. Andersen, Emily C. O’Brien, Iris Kindt, Peter Shrader, Chandna Vasandani, et al. “US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.J Clin Lipidol 10, no. 5 (2016): 1223–29. https://doi.org/10.1016/j.jacl.2016.07.011.
Ahmad ZS, Andersen RL, Andersen LH, O’Brien EC, Kindt I, Shrader P, et al. US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry. J Clin Lipidol. 2016;10(5):1223–9.
Ahmad, Zahid S., et al. “US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.J Clin Lipidol, vol. 10, no. 5, 2016, pp. 1223–29. Pubmed, doi:10.1016/j.jacl.2016.07.011.
Ahmad ZS, Andersen RL, Andersen LH, O’Brien EC, Kindt I, Shrader P, Vasandani C, Newman CB, deGoma EM, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Kullo IJ, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW. US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry. J Clin Lipidol. 2016;10(5):1223–1229.
Journal cover image

Published In

J Clin Lipidol

DOI

ISSN

1933-2874

Publication Date

2016

Volume

10

Issue

5

Start / End Page

1223 / 1229

Location

United States

Related Subject Headings

  • United States
  • Registries
  • Physicians
  • Middle Aged
  • Male
  • Hyperlipoproteinemia Type II
  • Humans
  • Female
  • Databases, Factual
  • Cross-Sectional Studies