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Flavivirus RNA transactions from viral entry to genome replication.

Publication ,  Journal Article
Garcia-Blanco, MA; Vasudevan, SG; Bradrick, SS; Nicchitta, C
Published in: Antiviral Res
October 2016

Upon release of the ∼11 kb single-stranded positive polarity dengue virus genomic RNA (gRNA) into the cytoplasm of an infected cell, it serves as the template for translation of the viral polyprotein, which is cleaved into three structural and seven non-structural proteins. The structural organization of the viral replication complex and RNA is not known but it is increasingly becoming evident that the viral gRNA and replication intermediates adopt unique structural features and localize to discrete regions in the infected cell. Both structure and location play multiple roles ranging from evasion of innate immune response to recruitment of viral and host proteins for translation and replication of the message. This review visits the various transactions that the viral gRNA undergoes between entry and RNA synthesis with the view that some of these events may be targeted by antiviral compounds. This article forms part of a symposium on flavivirus drug discovery in Antiviral Research.

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Published In

Antiviral Res

DOI

EISSN

1872-9096

Publication Date

October 2016

Volume

134

Start / End Page

244 / 249

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Virus Internalization
  • Virology
  • RNA, Viral
  • Humans
  • Host-Pathogen Interactions
  • Genome, Viral
  • Flavivirus
  • Dengue Virus
  • DNA Replication
 

Citation

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Garcia-Blanco, M. A., Vasudevan, S. G., Bradrick, S. S., & Nicchitta, C. (2016). Flavivirus RNA transactions from viral entry to genome replication. Antiviral Res, 134, 244–249. https://doi.org/10.1016/j.antiviral.2016.09.010
Garcia-Blanco, Mariano A., Subhash G. Vasudevan, Shelton S. Bradrick, and Christopher Nicchitta. “Flavivirus RNA transactions from viral entry to genome replication.Antiviral Res 134 (October 2016): 244–49. https://doi.org/10.1016/j.antiviral.2016.09.010.
Garcia-Blanco MA, Vasudevan SG, Bradrick SS, Nicchitta C. Flavivirus RNA transactions from viral entry to genome replication. Antiviral Res. 2016 Oct;134:244–9.
Garcia-Blanco, Mariano A., et al. “Flavivirus RNA transactions from viral entry to genome replication.Antiviral Res, vol. 134, Oct. 2016, pp. 244–49. Pubmed, doi:10.1016/j.antiviral.2016.09.010.
Garcia-Blanco MA, Vasudevan SG, Bradrick SS, Nicchitta C. Flavivirus RNA transactions from viral entry to genome replication. Antiviral Res. 2016 Oct;134:244–249.
Journal cover image

Published In

Antiviral Res

DOI

EISSN

1872-9096

Publication Date

October 2016

Volume

134

Start / End Page

244 / 249

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Virus Internalization
  • Virology
  • RNA, Viral
  • Humans
  • Host-Pathogen Interactions
  • Genome, Viral
  • Flavivirus
  • Dengue Virus
  • DNA Replication