Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs.
Publication
, Journal Article
Naggie, S; Muir, AJ
Published in: Annu Rev Med
January 14, 2017
The current standard of care for the treatment of hepatitis C virus (HCV) consists of interferon-free direct-acting antiviral (DAA) regimens, including combinations of DAAs and fixed-dose combination pills. DAAs for HCV are likely to be heralded as one of medicine's greatest advancements. Viral eradication rates are pushing 100% for many HCV-infected populations, including patients with HIV/HCV coinfection, decompensated cirrhosis, liver and kidney transplants, and end-stage liver disease. We highlight the greatest successes of combination DAA therapies, discuss the ongoing challenges, and identify the remaining patient subgroups with unmet medical needs.
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Published In
Annu Rev Med
DOI
EISSN
1545-326X
Publication Date
January 14, 2017
Volume
68
Start / End Page
345 / 358
Location
United States
Related Subject Headings
- Treatment Failure
- Secondary Prevention
- Recurrence
- Liver Transplantation
- Liver Cirrhosis
- Kidney Failure, Chronic
- Humans
- Hepatitis C
- Hepacivirus
- HIV Infections
Citation
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ICMJE
MLA
NLM
Naggie, S., & Muir, A. J. (2017). Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs. Annu Rev Med, 68, 345–358. https://doi.org/10.1146/annurev-med-052915-015720
Naggie, Susanna, and Andrew J. Muir. “Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs.” Annu Rev Med 68 (January 14, 2017): 345–58. https://doi.org/10.1146/annurev-med-052915-015720.
Naggie S, Muir AJ. Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs. Annu Rev Med. 2017 Jan 14;68:345–58.
Naggie, Susanna, and Andrew J. Muir. “Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs.” Annu Rev Med, vol. 68, Jan. 2017, pp. 345–58. Pubmed, doi:10.1146/annurev-med-052915-015720.
Naggie S, Muir AJ. Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs. Annu Rev Med. 2017 Jan 14;68:345–358.
Published In
Annu Rev Med
DOI
EISSN
1545-326X
Publication Date
January 14, 2017
Volume
68
Start / End Page
345 / 358
Location
United States
Related Subject Headings
- Treatment Failure
- Secondary Prevention
- Recurrence
- Liver Transplantation
- Liver Cirrhosis
- Kidney Failure, Chronic
- Humans
- Hepatitis C
- Hepacivirus
- HIV Infections