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Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis.

Publication ,  Journal Article
Erskine, HE; Norman, RE; Ferrari, AJ; Chan, GCK; Copeland, WE; Whiteford, HA; Scott, JG
Published in: J Am Acad Child Adolesc Psychiatry
October 2016

OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) are common externalizing disorders. Despite previous research demonstrating that both are longitudinally associated with adverse outcomes, there have been no systematic reviews examining all of the available evidence linking ADHD and CD with a range of health and psychosocial outcomes. METHOD: Electronic databases (EMBASE, Medline, and PsycINFO) were searched for studies published from 1980 up to March 2015. Published cohort and case-control studies were included if they reported a longitudinal association between ADHD or CD and adverse outcomes with a minimum follow-up of 2 years. Outcomes with sufficient data were pooled in a random effects meta-analysis to give overall odds ratios (ORs) with corresponding 95% CIs. RESULTS: Of the 278 studies assessed, 114 met inclusion criteria and 98 were used in subsequent meta-analyses. ADHD was associated with adverse outcomes including academic achievement (e.g. failure to complete high school; odds ratio [OR] = 3.7, 95% CIs 2.0-7.0), other mental and substance use disorders (e.g. depression; OR = 2.3, 1.5-3.7), criminality (e.g. arrest; OR = 2.4, 1.5-3.8), and employment (e.g., unemployment; OR = 2.0, 1.0-3.9). CD was associated with outcomes relating to academic achievement (e.g. failure to complete high school; OR = 2.7, 1.5-4.7), other mental and substance use disorders (e.g., illicit drug use; OR = 2.1, 1.7-2.6), and criminality (e.g. violence; OR = 3.5, 2.3-5.3). CONCLUSION: This study demonstrated that ADHD and CD are associated with disability beyond immediate health loss. Although the analyses could not determine the mechanisms behind these longitudinal associations, they demonstrate the importance of addressing ADHD and CD early in life so as to potentially avert a wide range of future adverse outcomes.

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Published In

J Am Acad Child Adolesc Psychiatry

DOI

EISSN

1527-5418

Publication Date

October 2016

Volume

55

Issue

10

Start / End Page

841 / 850

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Longitudinal Studies
  • Humans
  • Developmental & Child Psychology
  • Databases, Factual
  • Conduct Disorder
  • Cohort Studies
  • Case-Control Studies
  • Attention Deficit Disorder with Hyperactivity
  • 5201 Applied and developmental psychology
 

Citation

APA
Chicago
ICMJE
MLA
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Erskine, H. E., Norman, R. E., Ferrari, A. J., Chan, G. C. K., Copeland, W. E., Whiteford, H. A., & Scott, J. G. (2016). Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis. J Am Acad Child Adolesc Psychiatry, 55(10), 841–850. https://doi.org/10.1016/j.jaac.2016.06.016
Erskine, Holly E., Rosana E. Norman, Alize J. Ferrari, Gary C. K. Chan, William E. Copeland, Harvey A. Whiteford, and James G. Scott. “Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis.J Am Acad Child Adolesc Psychiatry 55, no. 10 (October 2016): 841–50. https://doi.org/10.1016/j.jaac.2016.06.016.
Erskine HE, Norman RE, Ferrari AJ, Chan GCK, Copeland WE, Whiteford HA, et al. Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis. J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):841–50.
Erskine, Holly E., et al. “Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis.J Am Acad Child Adolesc Psychiatry, vol. 55, no. 10, Oct. 2016, pp. 841–50. Pubmed, doi:10.1016/j.jaac.2016.06.016.
Erskine HE, Norman RE, Ferrari AJ, Chan GCK, Copeland WE, Whiteford HA, Scott JG. Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis. J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):841–850.
Journal cover image

Published In

J Am Acad Child Adolesc Psychiatry

DOI

EISSN

1527-5418

Publication Date

October 2016

Volume

55

Issue

10

Start / End Page

841 / 850

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Longitudinal Studies
  • Humans
  • Developmental & Child Psychology
  • Databases, Factual
  • Conduct Disorder
  • Cohort Studies
  • Case-Control Studies
  • Attention Deficit Disorder with Hyperactivity
  • 5201 Applied and developmental psychology