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Autofluorescence of choroidal nevus in 64 cases.

Publication ,  Journal Article
Shields, CL; Pirondini, C; Bianciotto, C; Materin, MA; Harmon, SA; Shields, JA
Published in: Retina
October 2008

PURPOSE: To describe the autofluorescence features of choroidal nevi. DESIGN: Noncomparative case series. PARTICIPANTS: Sixty-four consecutive patients. METHODS: Correlation of fundus photography with autofluorescence photography. MAIN OUTCOME MEASURE: Autofluorescence features of choroidal nevus and overlying retinal pigment epithelium (RPE). RESULTS: The mean patient age was 62 years. The choroidal nevus was a mean of 5 mm from the optic disk and foveola. The mean tumor basal dimension was 5.0 mm and mean tumor thickness was 1.0 mm. The choroidal nevus showed hypoautofluorescence in 56%, isoautofluorescence in 19%, and hyperautofluorescence in 25%. The autofluorescence features appeared unaffected by tumor thickness, but increasing tumor base and disrupted overlying RPE appeared to produce slightly brighter autofluorescence. Nevi located in the macular region showed darker hypoautofluorescence than those outside the macular region. Overlying RPE hyperplasia, atrophy, and fibrous metaplasia were generally hypoautofluorescent. Drusen, subretinal fluid, and orange pigment were generally hyperautofluorescent. The brightest hyperautofluorescence was found with orange pigment. CONCLUSIONS: Choroidal nevus shows little intrinsic autofluorescence. Overlying RPE alterations show dramatic autofluorescence ranging from dark hypoautofluorescence of RPE atrophy to bright hyperautofluorescence of orange pigment.

Duke Scholars

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

October 2008

Volume

28

Issue

8

Start / End Page

1035 / 1043

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Retina
  • Photography
  • Ophthalmology & Optometry
  • Nevus, Pigmented
  • Nevus
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shields, C. L., Pirondini, C., Bianciotto, C., Materin, M. A., Harmon, S. A., & Shields, J. A. (2008). Autofluorescence of choroidal nevus in 64 cases. Retina, 28(8), 1035–1043. https://doi.org/10.1097/IAE.0b013e318181b94b
Shields, Carol L., Cesare Pirondini, Carlos Bianciotto, Miguel A. Materin, Sarah A. Harmon, and Jerry A. Shields. “Autofluorescence of choroidal nevus in 64 cases.Retina 28, no. 8 (October 2008): 1035–43. https://doi.org/10.1097/IAE.0b013e318181b94b.
Shields CL, Pirondini C, Bianciotto C, Materin MA, Harmon SA, Shields JA. Autofluorescence of choroidal nevus in 64 cases. Retina. 2008 Oct;28(8):1035–43.
Shields, Carol L., et al. “Autofluorescence of choroidal nevus in 64 cases.Retina, vol. 28, no. 8, Oct. 2008, pp. 1035–43. Pubmed, doi:10.1097/IAE.0b013e318181b94b.
Shields CL, Pirondini C, Bianciotto C, Materin MA, Harmon SA, Shields JA. Autofluorescence of choroidal nevus in 64 cases. Retina. 2008 Oct;28(8):1035–1043.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

October 2008

Volume

28

Issue

8

Start / End Page

1035 / 1043

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Retina
  • Photography
  • Ophthalmology & Optometry
  • Nevus, Pigmented
  • Nevus
  • Middle Aged
  • Male