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Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Publication ,  Journal Article
Pereira, TA; Syn, W-K; Pereira, FEL; Lambertucci, JR; Secor, WE; Diehl, AM
Published in: Int J Parasitol
December 2016

Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Failure to downregulate osteopontin during the chronic phase may explain why hepatosplenic subjects develop severe fibrosis.

Duke Scholars

Published In

Int J Parasitol

DOI

EISSN

1879-0135

Publication Date

December 2016

Volume

46

Issue

13-14

Start / End Page

829 / 832

Location

England

Related Subject Headings

  • Splenomegaly
  • Schistosomiasis mansoni
  • ROC Curve
  • Osteopontin
  • Mycology & Parasitology
  • Mice, Inbred CBA
  • Mice
  • Male
  • Longitudinal Studies
  • Liver Cirrhosis
 

Citation

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Chicago
ICMJE
MLA
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Pereira, T. A., Syn, W.-K., Pereira, F. E. L., Lambertucci, J. R., Secor, W. E., & Diehl, A. M. (2016). Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Int J Parasitol, 46(13–14), 829–832. https://doi.org/10.1016/j.ijpara.2016.08.004
Pereira, Thiago Almeida, Wing-Kin Syn, Fausto E. L. Pereira, José Roberto Lambertucci, William Evan Secor, and Anna Mae Diehl. “Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.Int J Parasitol 46, no. 13–14 (December 2016): 829–32. https://doi.org/10.1016/j.ijpara.2016.08.004.
Pereira TA, Syn W-K, Pereira FEL, Lambertucci JR, Secor WE, Diehl AM. Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Int J Parasitol. 2016 Dec;46(13–14):829–32.
Pereira, Thiago Almeida, et al. “Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.Int J Parasitol, vol. 46, no. 13–14, Dec. 2016, pp. 829–32. Pubmed, doi:10.1016/j.ijpara.2016.08.004.
Pereira TA, Syn W-K, Pereira FEL, Lambertucci JR, Secor WE, Diehl AM. Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Int J Parasitol. 2016 Dec;46(13–14):829–832.
Journal cover image

Published In

Int J Parasitol

DOI

EISSN

1879-0135

Publication Date

December 2016

Volume

46

Issue

13-14

Start / End Page

829 / 832

Location

England

Related Subject Headings

  • Splenomegaly
  • Schistosomiasis mansoni
  • ROC Curve
  • Osteopontin
  • Mycology & Parasitology
  • Mice, Inbred CBA
  • Mice
  • Male
  • Longitudinal Studies
  • Liver Cirrhosis