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Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair.

Publication ,  Journal Article
Pang, J; Zelken, J; Dorafshar, AH; Strouse, JJ; Redett, R
Published in: Cleft Palate Craniofac J
November 2014

Cleft lip and palate can be associated with coagulopathy. Here, we report the first known case of congenital platelet disorder and von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair. After identifying the underlying pathology, platelet infusions and aminocaproic acid were given to decrease bleeding from a second surgical procedure. Whole exome sequencing identified a von Willebrand factor gene mutation, an adenine to guanine substitution at the c.475A location. A high index of suspicion should be had for coagulopathy in patients with syndromic cleft lip and palate.

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Published In

Cleft Palate Craniofac J

DOI

EISSN

1545-1569

Publication Date

November 2014

Volume

51

Issue

6

Start / End Page

740 / 742

Location

United States

Related Subject Headings

  • von Willebrand Diseases
  • Postoperative Complications
  • Male
  • Infant
  • Humans
  • Hemorrhage
  • Diagnosis, Differential
  • Dentistry
  • Cleft Palate
  • Cleft Lip
 

Citation

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ICMJE
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Pang, J., Zelken, J., Dorafshar, A. H., Strouse, J. J., & Redett, R. (2014). Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair. Cleft Palate Craniofac J, 51(6), 740–742. https://doi.org/10.1597/13-186
Pang, John, Jonathan Zelken, Amir H. Dorafshar, John J. Strouse, and Richard Redett. “Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair.Cleft Palate Craniofac J 51, no. 6 (November 2014): 740–42. https://doi.org/10.1597/13-186.
Pang J, Zelken J, Dorafshar AH, Strouse JJ, Redett R. Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair. Cleft Palate Craniofac J. 2014 Nov;51(6):740–2.
Pang, John, et al. “Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair.Cleft Palate Craniofac J, vol. 51, no. 6, Nov. 2014, pp. 740–42. Pubmed, doi:10.1597/13-186.
Pang J, Zelken J, Dorafshar AH, Strouse JJ, Redett R. Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair. Cleft Palate Craniofac J. 2014 Nov;51(6):740–742.

Published In

Cleft Palate Craniofac J

DOI

EISSN

1545-1569

Publication Date

November 2014

Volume

51

Issue

6

Start / End Page

740 / 742

Location

United States

Related Subject Headings

  • von Willebrand Diseases
  • Postoperative Complications
  • Male
  • Infant
  • Humans
  • Hemorrhage
  • Diagnosis, Differential
  • Dentistry
  • Cleft Palate
  • Cleft Lip