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High rates of recurrent biliary tract obstruction in children with sickle cell disease.

Publication ,  Journal Article
Amoako, MO; Casella, JF; Strouse, JJ
Published in: Pediatr Blood Cancer
April 2013

BACKGROUND: Individuals with sickle cell disease (SCD) have an increased risk of cholelithiasis from bilirubin stones. Symptomatic biliary tract disease (BTD) includes acute and chronic cholecystitis, obstruction of the common bile duct (CBD), cholangitis, and gallstone pancreatitis. Cholecystectomy is the main treatment strategy for symptomatic patients; however, the prevalence of recurrent BTD following cholecystectomy has not been systematically evaluated. We conducted a retrospective cohort study to describe the recurrence of BTD after cholecystectomy and characterize risk factors for recurrent disease. PROCEDURE: We identified patients <22 years of age who presented to the Johns Hopkins Children Center with symptomatic BTD from July 1993 to June 2008. RESULTS: We identified 56 patients with a total of 76 episodes of symptomatic BTD (median age at first event 15.9, range 4.6-21.5 years). Eleven of the 56 patients (19.6%) had at least one episode of recurrent symptomatic BTD (median follow-up of 5.3 years). Baseline characteristics were similar between the patients with a single episode of BTD and those with recurrent BTD. CONCLUSIONS: These results demonstrate that recurrent BTD is a frequent complication of SCD (20% by age 4 years) and often presents as CBD obstruction by stone, despite cholecystectomy. In our cohort, recurrence was not associated with age at first episode, baseline total bilirubin, gender, or genotype of SCD.

Duke Scholars

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

April 2013

Volume

60

Issue

4

Start / End Page

650 / 652

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Female
  • Cohort Studies
  • Chronic Disease
  • Cholestasis
 

Citation

APA
Chicago
ICMJE
MLA
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Amoako, M. O., Casella, J. F., & Strouse, J. J. (2013). High rates of recurrent biliary tract obstruction in children with sickle cell disease. Pediatr Blood Cancer, 60(4), 650–652. https://doi.org/10.1002/pbc.24413
Amoako, Martha O., James F. Casella, and John J. Strouse. “High rates of recurrent biliary tract obstruction in children with sickle cell disease.Pediatr Blood Cancer 60, no. 4 (April 2013): 650–52. https://doi.org/10.1002/pbc.24413.
Amoako MO, Casella JF, Strouse JJ. High rates of recurrent biliary tract obstruction in children with sickle cell disease. Pediatr Blood Cancer. 2013 Apr;60(4):650–2.
Amoako, Martha O., et al. “High rates of recurrent biliary tract obstruction in children with sickle cell disease.Pediatr Blood Cancer, vol. 60, no. 4, Apr. 2013, pp. 650–52. Pubmed, doi:10.1002/pbc.24413.
Amoako MO, Casella JF, Strouse JJ. High rates of recurrent biliary tract obstruction in children with sickle cell disease. Pediatr Blood Cancer. 2013 Apr;60(4):650–652.
Journal cover image

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

April 2013

Volume

60

Issue

4

Start / End Page

650 / 652

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Female
  • Cohort Studies
  • Chronic Disease
  • Cholestasis