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Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy.

Publication ,  Journal Article
Beverung, LM; Strouse, JJ; Hulbert, ML; Neville, K; Liem, RI; Inusa, B; Fuh, B; King, A; Meier, ER; Casella, J; DeBaun, MR; Panepinto, JA ...
Published in: Am J Hematol
February 2015

The completion of the Multicenter Silent Infarct Transfusion Trial demonstrated that children with pre-existing silent cerebral infarct and sickle cell anemia (SCA) who received regular blood transfusion therapy had a 58% relative risk reduction of infarct recurrence when compared to observation. However, the total benefit of blood transfusion therapy, as assessed by the parents, was not measured against the burden of monthly blood transfusion therapy. In this planned ancillary study, we tested the hypothesis that a patient centered outcome, health-related quality of life (HRQL), would be greater in participants randomly assigned to the blood transfusion therapy group than the observation group. A total of 89% (175 of 196) of the randomly allocated participants had evaluable entry and exit HRQL evaluations. The increase in Change in Health, measured as the child's health being better, was significantly greater for the transfusion group than the observation group (difference estimate = -0.54, P ≤ 0.001). This study provides the first evidence that children with SCA who received regular blood transfusion therapy felt better and had better overall HRQL than those who did not receive transfusion therapy.

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Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

February 2015

Volume

90

Issue

2

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Quality of Life
  • Patient-Centered Care
  • Male
  • Immunology
  • Humans
  • Female
  • Child, Preschool
 

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Beverung, L. M., Strouse, J. J., Hulbert, M. L., Neville, K., Liem, R. I., Inusa, B., … SIT trial investigators. (2015). Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. Am J Hematol, 90(2), 139–143. https://doi.org/10.1002/ajh.23877
Beverung, Lauren M., John J. Strouse, Monica L. Hulbert, Kathleen Neville, Robert I. Liem, Baba Inusa, Beng Fuh, et al. “Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy.Am J Hematol 90, no. 2 (February 2015): 139–43. https://doi.org/10.1002/ajh.23877.
Beverung LM, Strouse JJ, Hulbert ML, Neville K, Liem RI, Inusa B, et al. Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. Am J Hematol. 2015 Feb;90(2):139–43.
Beverung, Lauren M., et al. “Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy.Am J Hematol, vol. 90, no. 2, Feb. 2015, pp. 139–43. Pubmed, doi:10.1002/ajh.23877.
Beverung LM, Strouse JJ, Hulbert ML, Neville K, Liem RI, Inusa B, Fuh B, King A, Meier ER, Casella J, DeBaun MR, Panepinto JA, SIT trial investigators. Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. Am J Hematol. 2015 Feb;90(2):139–143.
Journal cover image

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

February 2015

Volume

90

Issue

2

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Quality of Life
  • Patient-Centered Care
  • Male
  • Immunology
  • Humans
  • Female
  • Child, Preschool