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Study design for genetic analysis in the Jackson Heart Study.

Publication ,  Journal Article
Wilson, JG; Rotimi, CN; Ekunwe, L; Royal, CDM; Crump, ME; Wyatt, SB; Steffes, MW; Adeyemo, A; Zhou, J; Taylor, HA; Jaquish, C
Published in: Ethnicity & disease
January 2005

This paper describes the preparation of genetic materials and the recruitment and initial characterization of a nested Family Study within the Jackson Heart Study (JHS) METHODS: Genomic DNA was prepared from all consenting JHS participants. In addition, family members of a subset of JHS participants were recruited to the JHS Family Study to allow heritability and linkage analyses and family-based association studies. Family Study participants completed the same questionnaires, measures, and procedures as all other JHS participants and provided blood samples for lymphocyte cryopreservation and transformation.DNA samples were obtained from 4726 JHS participants, including 1499 members of 291 families. In the family cohort, estimated heritabilities of body mass index, selected lipid levels, and blood pressure are highly significant, supporting the validity of the sample.The JHS data and genetic materials (DNA and cryopreserved cells) offer valuable opportunities to identify susceptibility alleles for common complex diseases by positional and candidate gene approaches.

Duke Scholars

Charmaine DM Royal
Author Charmaine DM Royal African & African American Studies

Published In

Ethnicity & disease

EISSN

1945-0826

ISSN

1049-510X

Publication Date

January 2005

Volume

15

Issue

4 Suppl 6

Start / End Page

S6-30-37

Related Subject Headings

  • Residence Characteristics
  • Research Design
  • Quantitative Trait, Heritable
  • Public Health
  • Prospective Studies
  • Pedigree
  • Patient Selection
  • Mississippi
  • Middle Aged
  • Male
 

Citation

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Wilson, J. G., Rotimi, C. N., Ekunwe, L., Royal, C. D. M., Crump, M. E., Wyatt, S. B., … Jaquish, C. (2005). Study design for genetic analysis in the Jackson Heart Study. Ethnicity & Disease, 15(4 Suppl 6), S6-30–37.
Wilson, James G., Charles N. Rotimi, Lynette Ekunwe, Charmaine D. M. Royal, Mary E. Crump, Sharon B. Wyatt, Michael W. Steffes, et al. “Study design for genetic analysis in the Jackson Heart Study.” Ethnicity & Disease 15, no. 4 Suppl 6 (January 2005): S6-30–37.
Wilson JG, Rotimi CN, Ekunwe L, Royal CDM, Crump ME, Wyatt SB, et al. Study design for genetic analysis in the Jackson Heart Study. Ethnicity & disease. 2005 Jan;15(4 Suppl 6):S6-30–7.
Wilson, James G., et al. “Study design for genetic analysis in the Jackson Heart Study.” Ethnicity & Disease, vol. 15, no. 4 Suppl 6, Jan. 2005, pp. S6-30–37.
Wilson JG, Rotimi CN, Ekunwe L, Royal CDM, Crump ME, Wyatt SB, Steffes MW, Adeyemo A, Zhou J, Taylor HA, Jaquish C. Study design for genetic analysis in the Jackson Heart Study. Ethnicity & disease. 2005 Jan;15(4 Suppl 6):S6-30–37.

Published In

Ethnicity & disease

EISSN

1945-0826

ISSN

1049-510X

Publication Date

January 2005

Volume

15

Issue

4 Suppl 6

Start / End Page

S6-30-37

Related Subject Headings

  • Residence Characteristics
  • Research Design
  • Quantitative Trait, Heritable
  • Public Health
  • Prospective Studies
  • Pedigree
  • Patient Selection
  • Mississippi
  • Middle Aged
  • Male