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Associations between dopamine D2 receptor availability and BMI depend on age.

Publication ,  Journal Article
Dang, LC; Samanez-Larkin, GR; Castrellon, JJ; Perkins, SF; Cowan, RL; Zald, DH
Published in: NeuroImage
September 2016

The dopamine D2/3 receptor subtypes (DRD2/3) are the most widely studied neurotransmitter biomarker in research on obesity, but results to date have been inconsistent, have typically involved small samples, and have rarely accounted for subjects' ages despite the large impact of age on DRD2/3 levels. We aimed to clarify the relation between DRD2/3 availability and BMI by examining this association in a large sample of subjects with BMI spanning the continuum from underweight to extremely obese.130 healthy subjects between 18 and 81years old underwent PET with [18F]fallypride, a high affinity DRD2/3 ligand.As expected, DRD2/3 availability declined with age. Critically, age significantly interacted with DRD2/3 availability in predicting BMI in the midbrain and striatal regions (caudate, putamen, and ventral striatum). Among subjects under 30years old, BMI was not associated with DRD2/3 availability. By contrast, among subjects over 30years old, BMI was positively associated with DRD2/3 availability in the midbrain, putamen, and ventral striatum.The present results are incompatible with the prominent dopaminergic hypofunction hypothesis that proposes that a reduction in DRD2/3 availability is associated with increased BMI, and highlights the importance of age in assessing correlates of DRD2/3 function.

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Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

September 2016

Volume

138

Start / End Page

176 / 183

Related Subject Headings

  • Young Adult
  • Tissue Distribution
  • Statistics as Topic
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Receptors, Dopamine D3
  • Receptors, Dopamine D2
  • Radiopharmaceuticals
  • Pyrrolidines
  • Positron-Emission Tomography
 

Citation

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Dang, L. C., Samanez-Larkin, G. R., Castrellon, J. J., Perkins, S. F., Cowan, R. L., & Zald, D. H. (2016). Associations between dopamine D2 receptor availability and BMI depend on age. NeuroImage, 138, 176–183. https://doi.org/10.1016/j.neuroimage.2016.05.044
Dang, Linh C., Gregory R. Samanez-Larkin, Jaime J. Castrellon, Scott F. Perkins, Ronald L. Cowan, and David H. Zald. “Associations between dopamine D2 receptor availability and BMI depend on age.NeuroImage 138 (September 2016): 176–83. https://doi.org/10.1016/j.neuroimage.2016.05.044.
Dang LC, Samanez-Larkin GR, Castrellon JJ, Perkins SF, Cowan RL, Zald DH. Associations between dopamine D2 receptor availability and BMI depend on age. NeuroImage. 2016 Sep;138:176–83.
Dang, Linh C., et al. “Associations between dopamine D2 receptor availability and BMI depend on age.NeuroImage, vol. 138, Sept. 2016, pp. 176–83. Epmc, doi:10.1016/j.neuroimage.2016.05.044.
Dang LC, Samanez-Larkin GR, Castrellon JJ, Perkins SF, Cowan RL, Zald DH. Associations between dopamine D2 receptor availability and BMI depend on age. NeuroImage. 2016 Sep;138:176–183.

Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

September 2016

Volume

138

Start / End Page

176 / 183

Related Subject Headings

  • Young Adult
  • Tissue Distribution
  • Statistics as Topic
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Receptors, Dopamine D3
  • Receptors, Dopamine D2
  • Radiopharmaceuticals
  • Pyrrolidines
  • Positron-Emission Tomography