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Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years.

Publication ,  Journal Article
Hossain, MJ; Xie, L; Lang, JE; Wysocki, TT; Shaffer, TH; Bunnell, HT
Published in: J Biom Biostat
January 2015

Asthma and obesity are two significant public health problems that both originate in early childhood and have shared risk factors and manifestations. Studies suggest a strong association between asthma development and subsequent accelerated weight gain. Children are diagnosed with asthma in early childhood and are often exposed to factors associated with rapid weight gain. This article intends to demonstrate an innovative application of the piecewise mixed effects model to characterize the difference in the temporal rate of change in BMIz, the standardized scores of body mass index and weight-for-length that measure weight status, before and after asthma diagnosis in children younger than 5 years. The data consist of unique sequences from 1194 children's clinic visits during the first 5 years of life. We used a knot at the time of diagnosis and detected a differential weight-gain pattern before and after asthma diagnosis. The pre- and post-asthma-diagnosis weight-gain patterns further differ by sex and race-ethnicity. After asthma diagnosis, female children showed a higher increase in the rate of change in BMIz than males. Non-Hispanic African Americans and Hispanics had higher post-diagnosis rates of change in BMIz than Caucasians. The differential weight-gain patterns between male and female children were mainly contributed by Caucasian children. These findings could have important implications in the clinical care of children after asthma diagnosis.

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Published In

J Biom Biostat

DOI

ISSN

2155-6180

Publication Date

January 2015

Volume

6

Issue

4

Start / End Page

248

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hossain, M. J., Xie, L., Lang, J. E., Wysocki, T. T., Shaffer, T. H., & Bunnell, H. T. (2015). Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years. J Biom Biostat, 6(4), 248. https://doi.org/10.4172/2155-6180.1000248
Hossain, Md Jobayer, Li Xie, Jason E. Lang, Timothy T. Wysocki, Thomas H. Shaffer, and H Timothy Bunnell. “Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years.J Biom Biostat 6, no. 4 (January 2015): 248. https://doi.org/10.4172/2155-6180.1000248.
Hossain MJ, Xie L, Lang JE, Wysocki TT, Shaffer TH, Bunnell HT. Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years. J Biom Biostat. 2015 Jan;6(4):248.
Hossain, Md Jobayer, et al. “Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years.J Biom Biostat, vol. 6, no. 4, Jan. 2015, p. 248. Pubmed, doi:10.4172/2155-6180.1000248.
Hossain MJ, Xie L, Lang JE, Wysocki TT, Shaffer TH, Bunnell HT. Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years. J Biom Biostat. 2015 Jan;6(4):248.

Published In

J Biom Biostat

DOI

ISSN

2155-6180

Publication Date

January 2015

Volume

6

Issue

4

Start / End Page

248

Location

United States