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Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods.

Publication ,  Journal Article
Lang, JE; Mougey, EB; Allayee, H; Blake, KV; Lockey, R; Gong, Y; Hossain, J; Killen, K; Lima, JJ; Nemours Network for Asthma Research,
Published in: Contemp Clin Trials
March 2013

Uncontrolled asthma is a major cause of hospitalizations and emergency room visits. Factors including obesity, African ancestry and childhood are associated with increased asthma severity. Considering the high morbidity caused by asthma, relatively few classes of drugs exist to control this common disease. Therefore, new therapeutic strategies may be needed to reduce asthma's impact on public health. Data suggest that a high fat diet that is deficient in omega-3 fatty acids could promote both obesity and excessive inflammation, resulting in greater asthma severity. Small trials with supplemental omega-3 fatty acids have been conducted with encouraging but inconsistent results. The variability in response seen in past trials may be due to the past subjects' genetics (specifically ALOX5 rs59439148) or their particular asthma phenotypes. Therefore, the "Nutrigenetic response to Omega-3 Fatty acids in Obese Asthmatics (NOOA)" trial is currently underway and was designed as a randomized, double-blind, placebo controlled intervention study to determine if supplemental omega-3 fatty acids improves symptoms among obese adolescents and young adults with uncontrolled asthma. Here we report the design and rationale for the NOOA trial. Participants were given either 3.18 g daily of eicosapentaenoic acid and 822 mg daily docosahexaenoic acid, or matched control soy oil, for 24 weeks. Change in the asthma control questionnaire score was the primary outcome. Secondary outcomes included spirometry, impulse oscillometry, exacerbation rate, airway biomarkers, systemic inflammation, leukotriene biosynthesis and T-lymphocyte function. NOOA may lead to a new therapeutic treatment strategy and greater understanding of the mechanistic role of diet in the pathogenesis of asthma.

Duke Scholars

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

March 2013

Volume

34

Issue

2

Start / End Page

326 / 335

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • T-Lymphocytes, Regulatory
  • Surveys and Questionnaires
  • Spirometry
  • Public Health
  • Obesity
  • Nutrigenomics
  • Male
  • Inflammation Mediators
 

Citation

APA
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ICMJE
MLA
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Lang, J. E., Mougey, E. B., Allayee, H., Blake, K. V., Lockey, R., Gong, Y., … Nemours Network for Asthma Research, . (2013). Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. Contemp Clin Trials, 34(2), 326–335. https://doi.org/10.1016/j.cct.2012.12.009
Lang, Jason E., Edward B. Mougey, Hooman Allayee, Kathryn V. Blake, Richard Lockey, Yan Gong, Jobayer Hossain, Kelleigh Killen, John J. Lima, and John J. Nemours Network for Asthma Research. “Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods.Contemp Clin Trials 34, no. 2 (March 2013): 326–35. https://doi.org/10.1016/j.cct.2012.12.009.
Lang JE, Mougey EB, Allayee H, Blake KV, Lockey R, Gong Y, et al. Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. Contemp Clin Trials. 2013 Mar;34(2):326–35.
Lang, Jason E., et al. “Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods.Contemp Clin Trials, vol. 34, no. 2, Mar. 2013, pp. 326–35. Pubmed, doi:10.1016/j.cct.2012.12.009.
Lang JE, Mougey EB, Allayee H, Blake KV, Lockey R, Gong Y, Hossain J, Killen K, Lima JJ, Nemours Network for Asthma Research. Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. Contemp Clin Trials. 2013 Mar;34(2):326–335.
Journal cover image

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

March 2013

Volume

34

Issue

2

Start / End Page

326 / 335

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • T-Lymphocytes, Regulatory
  • Surveys and Questionnaires
  • Spirometry
  • Public Health
  • Obesity
  • Nutrigenomics
  • Male
  • Inflammation Mediators