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Obesity in children with poorly controlled asthma: Sex differences.

Publication ,  Journal Article
Lang, JE; Holbrook, JT; Wise, RA; Dixon, AE; Teague, WG; Wei, CY; Irvin, CG; Shade, D; Lima, JJ ...
Published in: Pediatr Pulmonol
September 2013

BACKGROUND: Obesity increases asthma risk, and may alter asthma severity. In adults, sex appears to modify the effect of obesity on asthma. Among children, the effect of sex on the relationship between obesity and asthma severity remains less clear, particularly when considering race. OBJECTIVE: To determine how obesity affects disease characteristics in a diverse cohort of children with poorly controlled asthma, and if obesity effects are altered by sex. DESIGN: We analyzed 306 children between 6 and 17 years of age with poorly controlled asthma enrolled in a 6-month trial assessing lansoprazole for asthma control. In this secondary analysis, we determined associations between obesity and symptom severity, spirometry, exacerbation risk, airway biomarkers, bronchial reactivity, and airflow perception. We used both a multivariate linear regression and longitudinal mixed-effect model to determine if obesity interacted with sex to affect asthma severity. RESULTS: Regardless of sex, BMI >95th percentile did not affect asthma control, exacerbation risk or airway biomarkers. Sex changed the effect of obesity on lung function (sex × obesity FEV1%, interaction P-value < 0.01, sex × obesity FEV1/FVC, interaction P-value = 0.03). Obese males had significantly worse airflow obstruction compared to non-obese males, while in females there was no obesity effect on airflow obstruction. In females, obesity was associated with significantly greater FEV1 and FVC, and a trend toward reduced airway reactivity. CONCLUSIONS: Obesity did not affect asthma control, airway markers or disease stability; however obesity did affect lung function in a sex-dependent manner. In males, obesity associated with reduced FEV1/FVC, and in females, obesity associated with substantially improved lung function.

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Published In

Pediatr Pulmonol

DOI

EISSN

1099-0496

Publication Date

September 2013

Volume

48

Issue

9

Start / End Page

847 / 856

Location

United States

Related Subject Headings

  • Vital Capacity
  • Spirometry
  • Sex Factors
  • Severity of Illness Index
  • Respiratory System
  • Proton Pump Inhibitors
  • Obesity
  • Male
  • Longitudinal Studies
  • Lansoprazole
 

Citation

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Lang, J. E., Holbrook, J. T., Wise, R. A., Dixon, A. E., Teague, W. G., Wei, C. Y., … American Lung Association-Asthma Clinical Research Centers, . (2013). Obesity in children with poorly controlled asthma: Sex differences. Pediatr Pulmonol, 48(9), 847–856. https://doi.org/10.1002/ppul.22707
Lang, Jason E., Janet T. Holbrook, Robert A. Wise, Anne E. Dixon, W Gerald Teague, Christine Y. Wei, Charles G. Irvin, David Shade, John J. Lima, and John J. American Lung Association-Asthma Clinical Research Centers. “Obesity in children with poorly controlled asthma: Sex differences.Pediatr Pulmonol 48, no. 9 (September 2013): 847–56. https://doi.org/10.1002/ppul.22707.
Lang JE, Holbrook JT, Wise RA, Dixon AE, Teague WG, Wei CY, et al. Obesity in children with poorly controlled asthma: Sex differences. Pediatr Pulmonol. 2013 Sep;48(9):847–56.
Lang, Jason E., et al. “Obesity in children with poorly controlled asthma: Sex differences.Pediatr Pulmonol, vol. 48, no. 9, Sept. 2013, pp. 847–56. Pubmed, doi:10.1002/ppul.22707.
Lang JE, Holbrook JT, Wise RA, Dixon AE, Teague WG, Wei CY, Irvin CG, Shade D, Lima JJ, American Lung Association-Asthma Clinical Research Centers. Obesity in children with poorly controlled asthma: Sex differences. Pediatr Pulmonol. 2013 Sep;48(9):847–856.
Journal cover image

Published In

Pediatr Pulmonol

DOI

EISSN

1099-0496

Publication Date

September 2013

Volume

48

Issue

9

Start / End Page

847 / 856

Location

United States

Related Subject Headings

  • Vital Capacity
  • Spirometry
  • Sex Factors
  • Severity of Illness Index
  • Respiratory System
  • Proton Pump Inhibitors
  • Obesity
  • Male
  • Longitudinal Studies
  • Lansoprazole