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Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics.

Publication ,  Journal Article
Lang, JE; Hossain, J; Dixon, AE; Shade, D; Wise, RA; Peters, SP; Lima, JJ; American Lung Association-Asthma Clinical Research Centers,
Published in: Chest
December 2011

BACKGROUND: The relationship between obesity and asthma remains inadequately defined. Studies about how obesity affects asthma control and lung function show conflicting results. Additional focus on the effect of age as a modifier may make clearer the interaction between obesity and asthma phenotype. We sought to use a diverse and well-phenotyped cohort of asthmatic patients to determine how age impacts the relationship between obesity and spirometry, peak flow variability, airflow perception, and asthma control. METHODS: The characteristics of 490 patients with mild persistent asthma taken from 2,794 study visits from a prospective trial studying strategies of step-down therapy were included in this post hoc analysis. A longitudinal mixed-effect model was used to determine if age affects the relationship between obesity and asthma characteristics, including spirometry, asthma control, airway pH, and perception of airflow changes. RESULTS: The effect of obesity on asthma outcomes changes with age and gender. Obese 6- to 11-year-old children had the largest reduction in lung function but reported relatively fewer asthma symptoms than did similar nonobese asthmatics. Obese 12- to 17-year-olds showed a trend toward greater airflow obstruction and asthma symptoms compared with nonobese asthmatics. Adults in general displayed few obesity-related alterations in asthma phenotype. Female gender among 12- to 17- and 18- to 44-year-olds was associated with greater obesity-related asthma impairment. CONCLUSIONS: Age is a significant effect modifier on the relationship between obesity and asthma phenotype. With increasing age, the influence of obesity on the asthma phenotype is generally reduced. The asthma phenotype may be most impacted by obesity among children and women. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00156819; URL: www.clinicaltrials.gov.

Duke Scholars

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

December 2011

Volume

140

Issue

6

Start / End Page

1524 / 1533

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Total Lung Capacity
  • Sex Factors
  • Severity of Illness Index
  • Risk Assessment
  • Respiratory System
  • Respiratory Function Tests
  • Reference Values
  • Prognosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lang, J. E., Hossain, J., Dixon, A. E., Shade, D., Wise, R. A., Peters, S. P., … American Lung Association-Asthma Clinical Research Centers, . (2011). Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics. Chest, 140(6), 1524–1533. https://doi.org/10.1378/chest.11-0675
Lang, Jason E., Jobayer Hossain, Anne E. Dixon, David Shade, Robert A. Wise, Stephen P. Peters, John J. Lima, and John J. American Lung Association-Asthma Clinical Research Centers. “Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics.Chest 140, no. 6 (December 2011): 1524–33. https://doi.org/10.1378/chest.11-0675.
Lang JE, Hossain J, Dixon AE, Shade D, Wise RA, Peters SP, et al. Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics. Chest. 2011 Dec;140(6):1524–33.
Lang, Jason E., et al. “Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics.Chest, vol. 140, no. 6, Dec. 2011, pp. 1524–33. Pubmed, doi:10.1378/chest.11-0675.
Lang JE, Hossain J, Dixon AE, Shade D, Wise RA, Peters SP, Lima JJ, American Lung Association-Asthma Clinical Research Centers. Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics. Chest. 2011 Dec;140(6):1524–1533.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

December 2011

Volume

140

Issue

6

Start / End Page

1524 / 1533

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Total Lung Capacity
  • Sex Factors
  • Severity of Illness Index
  • Risk Assessment
  • Respiratory System
  • Respiratory Function Tests
  • Reference Values
  • Prognosis