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Comparing Coordinated Versus Sequential Salpingo-Oophorectomy for BRCA1 and BRCA2 Mutation Carriers With Breast Cancer.

Publication ,  Journal Article
S Chapman, J; Roddy, E; Panighetti, A; Hwang, S; Crawford, B; Powell, B; Chen, L-M
Published in: Clin Breast Cancer
December 2016

BACKGROUND: Women with breast cancer who carry BRCA1 or BRCA2 mutations must also consider risk-reducing salpingo-oophorectomy (RRSO) and how to coordinate this procedure with their breast surgery. We report the factors associated with coordinated versus sequential surgery and compare the outcomes of each. PATIENTS AND METHODS: Patients in our cancer risk database who had breast cancer and a known deleterious BRCA1/2 mutation before undergoing breast surgery were included. Women who chose concurrent RRSO at the time of breast surgery were compared to those who did not. RESULTS: Sixty-two patients knew their mutation carrier status before undergoing breast cancer surgery. Forty-three patients (69%) opted for coordinated surgeries, and 19 (31%) underwent sequential surgeries at a median follow-up of 4.4 years. Women who underwent coordinated surgery were significantly older than those who chose sequential surgery (median age of 45 vs. 39 years; P = .025). There were no differences in comorbidities between groups. Patients who received neoadjuvant chemotherapy were more likely to undergo coordinated surgery (65% vs. 37%; P = .038). Sequential surgery patients had longer hospital stays (4.79 vs. 3.44 days, P = .01) and longer operating times (8.25 vs. 6.38 hours, P = .006) than patients who elected combined surgery. Postoperative complications were minor and were no more likely in either group (odds ratio, 4.76; 95% confidence interval, 0.56-40.6). CONCLUSION: Coordinating RRSO with breast surgery is associated with receipt of neoadjuvant chemotherapy, longer operating times, and hospital stays without an observed increase in complications. In the absence of risk, surgical options can be personalized.

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Published In

Clin Breast Cancer

DOI

EISSN

1938-0666

Publication Date

December 2016

Volume

16

Issue

6

Start / End Page

494 / 499

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Salpingectomy
  • Risk Factors
  • Retrospective Studies
  • Prophylactic Surgical Procedures
  • Postoperative Complications
  • Ovariectomy
  • Ovarian Neoplasms
  • Operative Time
  • Oncology & Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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S Chapman, J., Roddy, E., Panighetti, A., Hwang, S., Crawford, B., Powell, B., & Chen, L.-M. (2016). Comparing Coordinated Versus Sequential Salpingo-Oophorectomy for BRCA1 and BRCA2 Mutation Carriers With Breast Cancer. Clin Breast Cancer, 16(6), 494–499. https://doi.org/10.1016/j.clbc.2016.06.016
S Chapman, Jocelyn, Erika Roddy, Anna Panighetti, Shelley Hwang, Beth Crawford, Bethan Powell, and Lee-May Chen. “Comparing Coordinated Versus Sequential Salpingo-Oophorectomy for BRCA1 and BRCA2 Mutation Carriers With Breast Cancer.Clin Breast Cancer 16, no. 6 (December 2016): 494–99. https://doi.org/10.1016/j.clbc.2016.06.016.
S Chapman J, Roddy E, Panighetti A, Hwang S, Crawford B, Powell B, et al. Comparing Coordinated Versus Sequential Salpingo-Oophorectomy for BRCA1 and BRCA2 Mutation Carriers With Breast Cancer. Clin Breast Cancer. 2016 Dec;16(6):494–9.
S Chapman, Jocelyn, et al. “Comparing Coordinated Versus Sequential Salpingo-Oophorectomy for BRCA1 and BRCA2 Mutation Carriers With Breast Cancer.Clin Breast Cancer, vol. 16, no. 6, Dec. 2016, pp. 494–99. Pubmed, doi:10.1016/j.clbc.2016.06.016.
S Chapman J, Roddy E, Panighetti A, Hwang S, Crawford B, Powell B, Chen L-M. Comparing Coordinated Versus Sequential Salpingo-Oophorectomy for BRCA1 and BRCA2 Mutation Carriers With Breast Cancer. Clin Breast Cancer. 2016 Dec;16(6):494–499.
Journal cover image

Published In

Clin Breast Cancer

DOI

EISSN

1938-0666

Publication Date

December 2016

Volume

16

Issue

6

Start / End Page

494 / 499

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Salpingectomy
  • Risk Factors
  • Retrospective Studies
  • Prophylactic Surgical Procedures
  • Postoperative Complications
  • Ovariectomy
  • Ovarian Neoplasms
  • Operative Time
  • Oncology & Carcinogenesis