Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies.

Publication ,  Journal Article
Rasmussen, CB; Kjaer, SK; Albieri, V; Bandera, EV; Doherty, JA; Høgdall, E; Webb, PM; Jordan, SJ; Rossing, MA; Wicklund, KG; Goodman, MT ...
Published in: Am J Epidemiol
January 1, 2017

Inflammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk of epithelial ovarian cancer according to tumor behavior and histotype. We pooled data from 13 case-control studies, conducted between 1989 and 2009, from the Ovarian Cancer Association Consortium (OCAC), including 9,162 women with ovarian cancers, 2,354 women with borderline tumors, and 14,736 control participants. Study-specific odds ratios were estimated and subsequently combined into a pooled odds ratio using a random-effects model. A history of PID was associated with an increased risk of borderline tumors (pooled odds ratio (pOR) = 1.32, 95% confidence interval (CI): 1.10, 1.58). Women with at least 2 episodes of PID had a 2-fold increased risk of borderline tumors (pOR = 2.14, 95% CI: 1.08, 4.24). No association was observed between PID and ovarian cancer risk overall (pOR = 0.99, 95% CI: 0.83, 1.19); however, a statistically nonsignificantly increased risk of low-grade serous tumors (pOR = 1.48, 95% CI: 0.92, 2.38) was noted. In conclusion, PID was associated with an increased risk of borderline ovarian tumors, particularly among women who had had multiple episodes of PID. Although our results indicated a histotype-specific association with PID, the association of PID with ovarian cancer risk is still somewhat uncertain and requires further investigation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

January 1, 2017

Volume

185

Issue

1

Start / End Page

8 / 20

Location

United States

Related Subject Headings

  • Talc
  • Sterilization, Tubal
  • Risk Factors
  • Reproductive History
  • Protective Factors
  • Pelvic Inflammatory Disease
  • Ovarian Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Hysterectomy
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rasmussen, C. B., Kjaer, S. K., Albieri, V., Bandera, E. V., Doherty, J. A., Høgdall, E., … , on behalf of the Ovarian Cancer Association Consortium, . (2017). Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies. Am J Epidemiol, 185(1), 8–20. https://doi.org/10.1093/aje/kww161
Rasmussen, Christina B., Susanne K. Kjaer, Vanna Albieri, Elisa V. Bandera, Jennifer A. Doherty, Estrid Høgdall, Penelope M. Webb, et al. “Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies.Am J Epidemiol 185, no. 1 (January 1, 2017): 8–20. https://doi.org/10.1093/aje/kww161.
Rasmussen CB, Kjaer SK, Albieri V, Bandera EV, Doherty JA, Høgdall E, et al. Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies. Am J Epidemiol. 2017 Jan 1;185(1):8–20.
Rasmussen, Christina B., et al. “Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies.Am J Epidemiol, vol. 185, no. 1, Jan. 2017, pp. 8–20. Pubmed, doi:10.1093/aje/kww161.
Rasmussen CB, Kjaer SK, Albieri V, Bandera EV, Doherty JA, Høgdall E, Webb PM, Jordan SJ, Rossing MA, Wicklund KG, Goodman MT, Modugno F, Moysich KB, Ness RB, Edwards RP, Schildkraut JM, Berchuck A, Olson SH, Kiemeney LA, Massuger LFAG, Narod SA, Phelan CM, Anton-Culver H, Ziogas A, Wu AH, Pearce CL, Risch HA, Jensen A, , on behalf of the Ovarian Cancer Association Consortium. Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies. Am J Epidemiol. 2017 Jan 1;185(1):8–20.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

January 1, 2017

Volume

185

Issue

1

Start / End Page

8 / 20

Location

United States

Related Subject Headings

  • Talc
  • Sterilization, Tubal
  • Risk Factors
  • Reproductive History
  • Protective Factors
  • Pelvic Inflammatory Disease
  • Ovarian Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Hysterectomy
  • Humans