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Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds.

Publication ,  Journal Article
Banskota, S; Yousefpour, P; Chilkoti, A
Published in: Macromolecular bioscience
January 2017

The goal of drug delivery is to deliver therapeutics to the site of disease while reducing unwanted side effects. In recent years, a diverse variety of synthetic nano and microparticles have been developed as drug delivery systems. The success of these systems for drug delivery lies in their ability to overcome biological barriers such as the blood-brain barrier, to evade immune clearance and avoid nonspecific biodistribution. This Review provides an overview of recent advances in the design of biohybrid drug delivery systems, which combine cells with synthetic systems to overcome some of these biological hurdles. Examples include eukaryotic cells, such as stem cells, red blood cells, immune cells, platelets, and cancer cells that are used to carry drug-loaded synthetic particles. Synthetic particles can also be cloaked with naturally derived cell membranes and thereby evade immune clearance, exhibit prolonged systemic circulation, and target specific tissues by capitalizing on the interaction/homing tendency of certain cells and their membrane components to particular tissues. Different designs of cell-based biohybrid systems and their applications, as well as their promise and limitations, are discussed herein.

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Published In

Macromolecular bioscience

DOI

EISSN

1616-5195

ISSN

1616-5187

Publication Date

January 2017

Volume

17

Issue

1

Related Subject Headings

  • Polymers
  • Neoplasms
  • Humans
  • Drug Delivery Systems
  • Cells
  • Biocompatible Materials
  • Animals
  • 4003 Biomedical engineering
  • 3403 Macromolecular and materials chemistry
  • 0904 Chemical Engineering
 

Citation

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ICMJE
MLA
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Banskota, S., Yousefpour, P., & Chilkoti, A. (2017). Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds. Macromolecular Bioscience, 17(1). https://doi.org/10.1002/mabi.201600361
Banskota, Samagya, Parisa Yousefpour, and Ashutosh Chilkoti. “Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds.Macromolecular Bioscience 17, no. 1 (January 2017). https://doi.org/10.1002/mabi.201600361.
Banskota S, Yousefpour P, Chilkoti A. Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds. Macromolecular bioscience. 2017 Jan;17(1).
Banskota, Samagya, et al. “Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds.Macromolecular Bioscience, vol. 17, no. 1, Jan. 2017. Epmc, doi:10.1002/mabi.201600361.
Banskota S, Yousefpour P, Chilkoti A. Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds. Macromolecular bioscience. 2017 Jan;17(1).
Journal cover image

Published In

Macromolecular bioscience

DOI

EISSN

1616-5195

ISSN

1616-5187

Publication Date

January 2017

Volume

17

Issue

1

Related Subject Headings

  • Polymers
  • Neoplasms
  • Humans
  • Drug Delivery Systems
  • Cells
  • Biocompatible Materials
  • Animals
  • 4003 Biomedical engineering
  • 3403 Macromolecular and materials chemistry
  • 0904 Chemical Engineering