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Treatment of HCV in Renal Disease: Subtle Management Considerations in the Era of Direct-acting Antivirals.

Publication ,  Journal Article
Patel, YA; Muir, AJ
Published in: Curr Hepatol Rep
December 2016

Chronic hepatitis C virus (HCV) infection is burdensome in patients with chronic kidney disease and contributes to substantial liver-related and all-cause morbidity and mortality. HCV infection itself may cause kidney dysfunction, as exemplified through mixed cryoglobulinemic vasculitis. HCV is more prevalent in patients with significant kidney disease compared to the general population, and recent reports have shown inadvertent HCV transmission in U.S. hemodialysis centers. Further, HCV has been demonstrated to accelerate kidney dysfunction and is associated with worse clinical outcomes in patients with kidney disease. As such, the HCV-infected population with concurrent kidney disease is an important patient subgroup that warrants focused medical care and attention. With the advent of direct-acting antivirals (DAAs), the successful treatment of HCV is now a medical reality for many patients. Nuances in regimen selection and timing need to be considered when treating those with kidney dysfunction, particularly for those considering kidney transplantation.

Duke Scholars

Published In

Curr Hepatol Rep

DOI

ISSN

2195-9595

Publication Date

December 2016

Volume

15

Issue

4

Start / End Page

285 / 290

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, Y. A., & Muir, A. J. (2016). Treatment of HCV in Renal Disease: Subtle Management Considerations in the Era of Direct-acting Antivirals. Curr Hepatol Rep, 15(4), 285–290. https://doi.org/10.1007/s11901-016-0319-5
Patel, Yuval A., and Andrew J. Muir. “Treatment of HCV in Renal Disease: Subtle Management Considerations in the Era of Direct-acting Antivirals.Curr Hepatol Rep 15, no. 4 (December 2016): 285–90. https://doi.org/10.1007/s11901-016-0319-5.
Patel, Yuval A., and Andrew J. Muir. “Treatment of HCV in Renal Disease: Subtle Management Considerations in the Era of Direct-acting Antivirals.Curr Hepatol Rep, vol. 15, no. 4, Dec. 2016, pp. 285–90. Pubmed, doi:10.1007/s11901-016-0319-5.
Journal cover image

Published In

Curr Hepatol Rep

DOI

ISSN

2195-9595

Publication Date

December 2016

Volume

15

Issue

4

Start / End Page

285 / 290

Location

United States