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Trauma Induced Coagulopathy

Cell-mediated hemostasis

Publication ,  Chapter
Hoffman, M
January 1, 2016

The coagulation “cascade” with its intrinsic and extrinsic pathways is a widely accepted paradigm for coagulation. It accurately portrays the reactions in the common screening tests, the prothrombin time and activated partial thromboplastin time. However, it is not a good model of how hemostasis occurs in vivo. A cell-based model consisting of initiation, amplification, and propagation phases more closely reflects the physiologic hemostatic process. Localization of the coagulation reactions to appropriate cell surfaces is critical to effective hemostasis and limitation of thrombosis. While cells play critical roles in controlling hemostasis, tissue conditions including temperature and pH also strongly influence the hemostatic process. This means that our common screening coagulation tests are not good predictors of the risk of clinical bleeding, though they can be useful in directing transfusion therapy.

Duke Scholars

DOI

ISBN

9783319283067

Publication Date

January 1, 2016

Start / End Page

3 / 14
 

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Hoffman, M. (2016). Cell-mediated hemostasis. In Trauma Induced Coagulopathy (pp. 3–14). https://doi.org/10.1007/978-3-319-28308-1_1
Hoffman, M. “Cell-mediated hemostasis.” In Trauma Induced Coagulopathy, 3–14, 2016. https://doi.org/10.1007/978-3-319-28308-1_1.
Hoffman M. Cell-mediated hemostasis. In: Trauma Induced Coagulopathy. 2016. p. 3–14.
Hoffman, M. “Cell-mediated hemostasis.” Trauma Induced Coagulopathy, 2016, pp. 3–14. Scopus, doi:10.1007/978-3-319-28308-1_1.
Hoffman M. Cell-mediated hemostasis. Trauma Induced Coagulopathy. 2016. p. 3–14.
Journal cover image

DOI

ISBN

9783319283067

Publication Date

January 1, 2016

Start / End Page

3 / 14