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Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies.

Publication ,  Journal Article
Praestegaard, C; Jensen, A; Jensen, SM; Nielsen, TSS; Webb, PM; Nagle, CM; DeFazio, A; Australian Ovarian Cancer Study Group, ; Høgdall, E ...
Published in: Int J Cancer
June 1, 2017

Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08-1.28) and former smokers (pHR = 1.10, 95% CI: 1.02-1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01-3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00-1.23; former smoking: pHR = 1.12, 95% CI: 1.04-1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

June 1, 2017

Volume

140

Issue

11

Start / End Page

2422 / 2435

Location

United States

Related Subject Headings

  • Young Adult
  • Smoking
  • Risk Factors
  • Proportional Hazards Models
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nicotiana
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans
 

Citation

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Praestegaard, C., Jensen, A., Jensen, S. M., Nielsen, T. S. S., Webb, P. M., Nagle, C. M., … Ovarian Cancer Association Consortium, . (2017). Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies. Int J Cancer, 140(11), 2422–2435. https://doi.org/10.1002/ijc.30600
Praestegaard, Camilla, Allan Jensen, Signe M. Jensen, Thor S. S. Nielsen, Penelope M. Webb, Christina M. Nagle, Anna DeFazio, et al. “Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies.Int J Cancer 140, no. 11 (June 1, 2017): 2422–35. https://doi.org/10.1002/ijc.30600.
Praestegaard C, Jensen A, Jensen SM, Nielsen TSS, Webb PM, Nagle CM, et al. Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies. Int J Cancer. 2017 Jun 1;140(11):2422–35.
Praestegaard, Camilla, et al. “Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies.Int J Cancer, vol. 140, no. 11, June 2017, pp. 2422–35. Pubmed, doi:10.1002/ijc.30600.
Praestegaard C, Jensen A, Jensen SM, Nielsen TSS, Webb PM, Nagle CM, DeFazio A, Australian Ovarian Cancer Study Group, Høgdall E, Rossing MA, Doherty JA, Wicklund KG, Goodman MT, Modugno F, Moysich K, Ness RB, Edwards R, Matsuo K, Hosono S, Goode EL, Winham SJ, Fridley BL, Cramer DW, Terry KL, Schildkraut JM, Berchuck A, Bandera EV, Paddock LE, Massuger LF, Wentzensen N, Pharoah P, Song H, Whittemore A, McGuire V, Sieh W, Rothstein J, Anton-Culver H, Ziogas A, Menon U, Gayther SA, Ramus SJ, Gentry-Maharaj A, Wu AH, Pearce CL, Pike M, Lee AW, Sutphen R, Chang-Claude J, Risch HA, Kjaer SK, Ovarian Cancer Association Consortium. Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies. Int J Cancer. 2017 Jun 1;140(11):2422–2435.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

June 1, 2017

Volume

140

Issue

11

Start / End Page

2422 / 2435

Location

United States

Related Subject Headings

  • Young Adult
  • Smoking
  • Risk Factors
  • Proportional Hazards Models
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nicotiana
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans