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WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters.

Publication ,  Journal Article
Bache, S; Belley, M; Benning, R; Stanton, I; Therien, M; Yoshizumi, T; Adamovics, J; Oldham, M
Published in: Med Phys
June 2014

PURPOSE: Pre-clinical micro-radiation therapy studies often utilize very small beams (∼0.5-5mm), and require accurate dose delivery in order to effectively investigate treatment efficacy. Here we present a novel high-resolution absolute 3D dosimetry procedure, capable of ∼100-micron isotopic dosimetry in anatomically accurate rodent-morphic phantoms METHODS: Anatomically accurate rat-shaped 3D dosimeters were made using 3D printing techniques from outer body contours and spinal contours outlined on CT. The dosimeters were made from a radiochromic plastic material PRESAGE, and incorporated high-Z PRESASGE inserts mimicking the spine. A simulated 180-degree spinal arc treatment was delivered through a 2 step process: (i) cone-beam-CT image-guided positioning was performed to precisely position the rat-dosimeter for treatment on the XRad225 small animal irradiator, then (ii) treatment was delivered with a simulated spine-treatment with a 180-degree arc with 20mm x 10mm cone at 225 kVp. Dose distribution was determined from the optical density change using a high-resolution in-house optical-CT system. Absolute dosimetry was enabled through calibration against a novel nano-particle scintillation detector positioned in a channel in the center of the distribution. RESULTS: Sufficient contrast between regular PRESAGE (tissue equivalent) and high-Z PRESAGE (spinal insert) was observed to enable highly accurate image-guided alignment and targeting. The PRESAGE was found to have linear optical density (OD) change sensitivity with respect to dose (R(2) = 0.9993). Absolute dose for 360-second irradiation at isocenter was found to be 9.21Gy when measured with OD change, and 9.4Gy with nano-particle detector- an agreement within 2%. The 3D dose distribution was measured at 500-micron resolution CONCLUSION: This work demonstrates for the first time, the feasibility of accurate absolute 3D dose measurement in anatomically accurate rat phantoms containing variable density PRESAGE material (tissue equivalent and bone equivalent). This method enables precise treatment verification of micro-radiation therapies, and enhances the robustness of tumor radio-response studies. This work was supported by NIH R01CA100835.

Duke Scholars

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2014

Volume

41

Issue

6

Start / End Page

514 / 515

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bache, S., Belley, M., Benning, R., Stanton, I., Therien, M., Yoshizumi, T., … Oldham, M. (2014). WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters. Med Phys, 41(6), 514–515. https://doi.org/10.1118/1.4889471
Bache, S., M. Belley, R. Benning, I. Stanton, M. Therien, T. Yoshizumi, J. Adamovics, and M. Oldham. “WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters.Med Phys 41, no. 6 (June 2014): 514–15. https://doi.org/10.1118/1.4889471.
Bache S, Belley M, Benning R, Stanton I, Therien M, Yoshizumi T, et al. WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters. Med Phys. 2014 Jun;41(6):514–5.
Bache, S., et al. “WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters.Med Phys, vol. 41, no. 6, June 2014, pp. 514–15. Pubmed, doi:10.1118/1.4889471.
Bache S, Belley M, Benning R, Stanton I, Therien M, Yoshizumi T, Adamovics J, Oldham M. WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters. Med Phys. 2014 Jun;41(6):514–515.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2014

Volume

41

Issue

6

Start / End Page

514 / 515

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences