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Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins.

Publication ,  Journal Article
Ozer, I; Chilkoti, A
Published in: Bioconjugate chemistry
March 2017

As potent and selective therapeutic agents, peptides and proteins are an important class of drugs, but they typically have suboptimal pharmacokinetic profiles. One approach to solve this problem is their conjugation with "stealth" polymers. Conventional methods for conjugation of this class of polymers to peptides and proteins are typically carried out by reactions that have poor yield and provide limited control over the site of conjugation and the stoichiometry of the conjugate. To address these limitations, new chemical and biological approaches have been developed that provide new molecular tools in the bioconjugation toolbox to create stealth polymer conjugates of peptides and proteins with exquisite control over their properties. This review article highlights these recent advances in the synthesis of therapeutic peptide- and protein-stealth polymer conjugates.

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Published In

Bioconjugate chemistry

DOI

EISSN

1520-4812

ISSN

1043-1802

Publication Date

March 2017

Volume

28

Issue

3

Start / End Page

713 / 723

Related Subject Headings

  • Proteins
  • Polymers
  • Peptides
  • Organic Chemistry
  • Models, Molecular
  • Humans
  • Chemistry Techniques, Synthetic
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
 

Citation

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MLA
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Ozer, I., & Chilkoti, A. (2017). Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins. Bioconjugate Chemistry, 28(3), 713–723. https://doi.org/10.1021/acs.bioconjchem.6b00652
Ozer, Imran, and Ashutosh Chilkoti. “Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins.Bioconjugate Chemistry 28, no. 3 (March 2017): 713–23. https://doi.org/10.1021/acs.bioconjchem.6b00652.
Ozer I, Chilkoti A. Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins. Bioconjugate chemistry. 2017 Mar;28(3):713–23.
Ozer, Imran, and Ashutosh Chilkoti. “Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins.Bioconjugate Chemistry, vol. 28, no. 3, Mar. 2017, pp. 713–23. Epmc, doi:10.1021/acs.bioconjchem.6b00652.
Ozer I, Chilkoti A. Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins. Bioconjugate chemistry. 2017 Mar;28(3):713–723.
Journal cover image

Published In

Bioconjugate chemistry

DOI

EISSN

1520-4812

ISSN

1043-1802

Publication Date

March 2017

Volume

28

Issue

3

Start / End Page

713 / 723

Related Subject Headings

  • Proteins
  • Polymers
  • Peptides
  • Organic Chemistry
  • Models, Molecular
  • Humans
  • Chemistry Techniques, Synthetic
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology