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Translating Regenerative Medicine to the Clinic

Cord Blood Transplantation in Hematological and Metabolic Diseases

Publication ,  Chapter
Sun, JM; Kurtzberg, J
January 1, 2016

Umbilical cord blood (CB), as a source of hematopoietic stem and progenitor cells for hematopoietic reconstitution, has been used for over two decades in allogeneic transplantation to treat patients with hematological malignancies, bone marrow failure, immunodeficiency syndromes, hemoglobinopathies, and certain inherited metabolic disorders. CB banks have been established worldwide, and regulatory pathways for licensure of publicly banked units are in place in the USA and other countries around the world. CB is immunologically tolerant thereby expanding access to transplantation for patients unable to find a fully matched donor and, because of rapid availability, is also a unique option for treatment of children with otherwise lethal inherited metabolic diseases affecting the brain. CB is likely to be an important source of cells for use in the emerging fields of cellular therapies and regenerative medicine.

Duke Scholars

DOI

ISBN

9780128005484

Publication Date

January 1, 2016

Start / End Page

285 / 295
 

Citation

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Sun, J. M., & Kurtzberg, J. (2016). Cord Blood Transplantation in Hematological and Metabolic Diseases. In Translating Regenerative Medicine to the Clinic (pp. 285–295). https://doi.org/10.1016/B978-0-12-800548-4.00019-X
Sun, J. M., and J. Kurtzberg. “Cord Blood Transplantation in Hematological and Metabolic Diseases.” In Translating Regenerative Medicine to the Clinic, 285–95, 2016. https://doi.org/10.1016/B978-0-12-800548-4.00019-X.
Sun JM, Kurtzberg J. Cord Blood Transplantation in Hematological and Metabolic Diseases. In: Translating Regenerative Medicine to the Clinic. 2016. p. 285–95.
Sun, J. M., and J. Kurtzberg. “Cord Blood Transplantation in Hematological and Metabolic Diseases.” Translating Regenerative Medicine to the Clinic, 2016, pp. 285–95. Scopus, doi:10.1016/B978-0-12-800548-4.00019-X.
Sun JM, Kurtzberg J. Cord Blood Transplantation in Hematological and Metabolic Diseases. Translating Regenerative Medicine to the Clinic. 2016. p. 285–295.
Journal cover image

DOI

ISBN

9780128005484

Publication Date

January 1, 2016

Start / End Page

285 / 295