Skip to main content
Journal cover image

Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.

Publication ,  Journal Article
Chen, J; Wu, L; Wang, Y; Yin, J; Li, X; Wang, Z; Li, H; Zou, T; Qian, C; Li, C; Zhang, W; Zhou, H; Liu, Z
Published in: Tumour Biol
February 2016

Lung cancer is the first leading cause of cancer deaths. Chemotherapy toxicity is one of factors that limited the efficacy of platinum-based chemotherapy in lung cancer patients. Transporters and DNA repair genes play critical roles in occurrence of platinum-based chemotherapy toxicity. To investigate the relationships between transporter and DNA repair gene polymorphisms and platinum-based chemotherapy toxicity in lung cancer patients, we selected 60 polymorphisms in 14 transporters and DNA repair genes. The polymorphisms were genotyped in 317 lung cancer patients by Sequenom MassARRAY. Logistic regression was performed to estimate the association of toxicity outcome with the polymorphisms by PLINK. Our results showed that polymorphisms of SLC2A1 (rs3738514, rs4658, rs841844) were significantly related to overall toxicity. XRCC5 (rs1051685, rs6941) and AQP2 (10875989, rs3759125) polymorphisms were associated with hematologic toxicity. AQP2 polymorphisms (rs461872, rs7305534) were correlated with gastrointestinal toxicity. In conclusion, genotypes of these genes may be used to predict the platinum-based chemotherapy toxicity in lung cancer patients.

Duke Scholars

Published In

Tumour Biol

DOI

EISSN

1423-0380

Publication Date

February 2016

Volume

37

Issue

2

Start / End Page

2275 / 2284

Location

Netherlands

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Membrane Transport Proteins
  • Male
  • Lung Neoplasms
  • Ku Autoantigen
  • Humans
  • Glucose Transporter Type 1
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, J., Wu, L., Wang, Y., Yin, J., Li, X., Wang, Z., … Liu, Z. (2016). Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity. Tumour Biol, 37(2), 2275–2284. https://doi.org/10.1007/s13277-015-4048-0
Chen, Juan, Lin Wu, Ying Wang, Jiye Yin, Xiangping Li, Zhan Wang, Huihua Li, et al. “Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.Tumour Biol 37, no. 2 (February 2016): 2275–84. https://doi.org/10.1007/s13277-015-4048-0.
Chen J, Wu L, Wang Y, Yin J, Li X, Wang Z, et al. Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity. Tumour Biol. 2016 Feb;37(2):2275–84.
Chen, Juan, et al. “Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.Tumour Biol, vol. 37, no. 2, Feb. 2016, pp. 2275–84. Pubmed, doi:10.1007/s13277-015-4048-0.
Chen J, Wu L, Wang Y, Yin J, Li X, Wang Z, Li H, Zou T, Qian C, Li C, Zhang W, Zhou H, Liu Z. Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity. Tumour Biol. 2016 Feb;37(2):2275–2284.
Journal cover image

Published In

Tumour Biol

DOI

EISSN

1423-0380

Publication Date

February 2016

Volume

37

Issue

2

Start / End Page

2275 / 2284

Location

Netherlands

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Membrane Transport Proteins
  • Male
  • Lung Neoplasms
  • Ku Autoantigen
  • Humans
  • Glucose Transporter Type 1
  • Genotype