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Improving Medication Adherence in Cardiometabolic Disease: Practical and Regulatory Implications.

Publication ,  Journal Article
Ferdinand, KC; Senatore, FF; Clayton-Jeter, H; Cryer, DR; Lewin, JC; Nasser, SA; Fiuzat, M; Califf, RM
Published in: J Am Coll Cardiol
January 31, 2017

Medication nonadherence, a major problem in cardiovascular disease (CVD), contributes yearly to approximately 125,000 preventable deaths, which is partly attributable to only about one-half of CVD patients consistently taking prescribed life-saving medications. Current interest has focused on how labeling and education influence adherence. This paper summarizes the scope of CVD nonadherence, describes key U.S. Food and Drug Administration initiatives, and identifies potential targets for improvement. We describe key adherence factors, methods, and technological applications for simplifying regimens and enhancing adherence, and 4 areas where additional collaborative research and implementation involving the regulatory system and clinical community could substantially reduce nonadherence: 1) identifying monitoring methods; 2) improving the evidence base to better understand adherence; 3) developing patient/health provider team-based engagement strategies; and 4) alleviating health disparities. Alignment of U.S. Food and Drug Administration approaches to dissemination of information about appropriate use with clinical practice could improve adherence, and thereby reduce CVD death and disability.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

January 31, 2017

Volume

69

Issue

4

Start / End Page

437 / 451

Location

United States

Related Subject Headings

  • United States Food and Drug Administration
  • United States
  • Socioeconomic Factors
  • Patient Education as Topic
  • Medication Adherence
  • Information Dissemination
  • Humans
  • Health Promotion
  • Health Literacy
  • Drugs, Generic
 

Citation

APA
Chicago
ICMJE
MLA
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Ferdinand, K. C., Senatore, F. F., Clayton-Jeter, H., Cryer, D. R., Lewin, J. C., Nasser, S. A., … Califf, R. M. (2017). Improving Medication Adherence in Cardiometabolic Disease: Practical and Regulatory Implications. J Am Coll Cardiol, 69(4), 437–451. https://doi.org/10.1016/j.jacc.2016.11.034
Ferdinand, Keith C., Fortunato Fred Senatore, Helene Clayton-Jeter, Dennis R. Cryer, John C. Lewin, Samar A. Nasser, Mona Fiuzat, and Robert M. Califf. “Improving Medication Adherence in Cardiometabolic Disease: Practical and Regulatory Implications.J Am Coll Cardiol 69, no. 4 (January 31, 2017): 437–51. https://doi.org/10.1016/j.jacc.2016.11.034.
Ferdinand KC, Senatore FF, Clayton-Jeter H, Cryer DR, Lewin JC, Nasser SA, et al. Improving Medication Adherence in Cardiometabolic Disease: Practical and Regulatory Implications. J Am Coll Cardiol. 2017 Jan 31;69(4):437–51.
Ferdinand, Keith C., et al. “Improving Medication Adherence in Cardiometabolic Disease: Practical and Regulatory Implications.J Am Coll Cardiol, vol. 69, no. 4, Jan. 2017, pp. 437–51. Pubmed, doi:10.1016/j.jacc.2016.11.034.
Ferdinand KC, Senatore FF, Clayton-Jeter H, Cryer DR, Lewin JC, Nasser SA, Fiuzat M, Califf RM. Improving Medication Adherence in Cardiometabolic Disease: Practical and Regulatory Implications. J Am Coll Cardiol. 2017 Jan 31;69(4):437–451.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

January 31, 2017

Volume

69

Issue

4

Start / End Page

437 / 451

Location

United States

Related Subject Headings

  • United States Food and Drug Administration
  • United States
  • Socioeconomic Factors
  • Patient Education as Topic
  • Medication Adherence
  • Information Dissemination
  • Humans
  • Health Promotion
  • Health Literacy
  • Drugs, Generic