Skip to main content
Journal cover image

Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies.

Publication ,  Journal Article
Thompson, S; Kaptoge, S; White, I; Wood, A; Perry, P; Danesh, J; Emerging Risk Factors Collaboration
Published in: Int J Epidemiol
October 2010

BACKGROUND: Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges. METHODS: This article describes statistical approaches adopted in the Emerging Risk Factors Collaboration, in which primary data from more than 1 million participants in more than 100 prospective studies have been collated to enable detailed analyses of various risk markers in relation to incident cardiovascular disease outcomes. RESULTS: Analyses have been principally based on Cox proportional hazards regression models stratified by sex, undertaken in each study separately. Estimates of exposure-risk relationships, initially unadjusted and then adjusted for several confounders, have been combined over studies using meta-analysis. Methods for assessing the shape of exposure-risk associations and the proportional hazards assumption have been developed. Estimates of interactions have also been combined using meta-analysis, keeping separate within- and between-study information. Regression dilution bias caused by measurement error and within-person variation in exposures and confounders has been addressed through the analysis of repeat measurements to estimate corrected regression coefficients. These methods are exemplified by analysis of plasma fibrinogen and risk of coronary heart disease, and Stata code is made available. CONCLUSION: Increasing numbers of meta-analyses of individual participant data from observational data are being conducted to enhance the statistical power and detail of epidemiological studies. The statistical methods developed here can be used to address the needs of such analyses.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

October 2010

Volume

39

Issue

5

Start / End Page

1345 / 1359

Location

England

Related Subject Headings

  • Time Factors
  • Smoking
  • Sex Factors
  • Risk Factors
  • Proportional Hazards Models
  • Humans
  • Fibrinogen
  • Epidemiology
  • Epidemiologic Methods
  • Data Interpretation, Statistical
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Thompson, S., Kaptoge, S., White, I., Wood, A., Perry, P., Danesh, J., & Emerging Risk Factors Collaboration. (2010). Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. Int J Epidemiol, 39(5), 1345–1359. https://doi.org/10.1093/ije/dyq063
Thompson, Simon, Stephen Kaptoge, Ian White, Angela Wood, Philip Perry, John Danesh, and Emerging Risk Factors Collaboration. “Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies.Int J Epidemiol 39, no. 5 (October 2010): 1345–59. https://doi.org/10.1093/ije/dyq063.
Thompson S, Kaptoge S, White I, Wood A, Perry P, Danesh J, et al. Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. Int J Epidemiol. 2010 Oct;39(5):1345–59.
Thompson, Simon, et al. “Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies.Int J Epidemiol, vol. 39, no. 5, Oct. 2010, pp. 1345–59. Pubmed, doi:10.1093/ije/dyq063.
Thompson S, Kaptoge S, White I, Wood A, Perry P, Danesh J, Emerging Risk Factors Collaboration. Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. Int J Epidemiol. 2010 Oct;39(5):1345–1359.
Journal cover image

Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

October 2010

Volume

39

Issue

5

Start / End Page

1345 / 1359

Location

England

Related Subject Headings

  • Time Factors
  • Smoking
  • Sex Factors
  • Risk Factors
  • Proportional Hazards Models
  • Humans
  • Fibrinogen
  • Epidemiology
  • Epidemiologic Methods
  • Data Interpretation, Statistical