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Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction.

Publication ,  Journal Article
de Juan, E; Dickson, J; Hatchell, DL
Published in: Graefes Arch Clin Exp Ophthalmol
1989

Traction retinal detachment results in severe visual loss in many proliferative vitreoretinal disorders. Retinal glial cells participate in nearly all of the proliferative diseases involving the retina. In order to better understand the mechanism of vitreous traction we used phase-contrast and scanning electron microscopy to study the interaction of human retinal glial cells and rabbit dermal fibroblasts with collagen gels. To modify this interaction, we placed a peptide containing the arginine-glycine-aspartic acid sequence that competes for the cellular binding site of fibronectin onto the collagen gels. We found that both glial cells and fibroblasts attached to collagen fibers and pulled them centripetally. The cells extended their processes toward adjacent cells in the gel creating "strands" and traction in a self-promoting fashion. Despite a dramatic effect on fibroblast-mediated traction, the peptide had little effect on glial cells even at 3 mg/ml.

Duke Scholars

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1989

Volume

227

Issue

5

Start / End Page

494 / 498

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Retinal Diseases
  • Retina
  • Rabbits
  • Peptides
  • Ophthalmology & Optometry
  • Oligopeptides
  • Neuroglia
  • Microscopy, Electron, Scanning
  • Humans
 

Citation

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de Juan, E., Dickson, J., & Hatchell, D. L. (1989). Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction. Graefes Arch Clin Exp Ophthalmol, 227(5), 494–498. https://doi.org/10.1007/BF02172905
Juan, E. de, J. Dickson, and D. L. Hatchell. “Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction.Graefes Arch Clin Exp Ophthalmol 227, no. 5 (1989): 494–98. https://doi.org/10.1007/BF02172905.
de Juan E, Dickson J, Hatchell DL. Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction. Graefes Arch Clin Exp Ophthalmol. 1989;227(5):494–8.
de Juan, E., et al. “Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction.Graefes Arch Clin Exp Ophthalmol, vol. 227, no. 5, 1989, pp. 494–98. Pubmed, doi:10.1007/BF02172905.
de Juan E, Dickson J, Hatchell DL. Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction. Graefes Arch Clin Exp Ophthalmol. 1989;227(5):494–498.
Journal cover image

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1989

Volume

227

Issue

5

Start / End Page

494 / 498

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Retinal Diseases
  • Retina
  • Rabbits
  • Peptides
  • Ophthalmology & Optometry
  • Oligopeptides
  • Neuroglia
  • Microscopy, Electron, Scanning
  • Humans