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Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.

Publication ,  Journal Article
Chandrawati, R; Chang, JYH; Reina-Torres, E; Jumeaux, C; Sherwood, JM; Stamer, WD; Zelikin, AN; Overby, DR; Stevens, MM
Published in: Adv Mater
April 2017

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.

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Published In

Adv Mater

DOI

EISSN

1521-4095

Publication Date

April 2017

Volume

29

Issue

16

Location

Germany

Related Subject Headings

  • Nitric Oxide
  • Nanoscience & Nanotechnology
  • Mice
  • Intraocular Pressure
  • Glaucoma
  • Biocatalysis
  • Aqueous Humor
  • Animals
  • 51 Physical sciences
  • 40 Engineering
 

Citation

APA
Chicago
ICMJE
MLA
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Chandrawati, R., Chang, J. Y. H., Reina-Torres, E., Jumeaux, C., Sherwood, J. M., Stamer, W. D., … Stevens, M. M. (2017). Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma. Adv Mater, 29(16). https://doi.org/10.1002/adma.201604932
Chandrawati, Rona, Jason Y. H. Chang, Ester Reina-Torres, Coline Jumeaux, Joseph M. Sherwood, W Daniel Stamer, Alexander N. Zelikin, Darryl R. Overby, and Molly M. Stevens. “Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.Adv Mater 29, no. 16 (April 2017). https://doi.org/10.1002/adma.201604932.
Chandrawati R, Chang JYH, Reina-Torres E, Jumeaux C, Sherwood JM, Stamer WD, et al. Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma. Adv Mater. 2017 Apr;29(16).
Chandrawati, Rona, et al. “Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.Adv Mater, vol. 29, no. 16, Apr. 2017. Pubmed, doi:10.1002/adma.201604932.
Chandrawati R, Chang JYH, Reina-Torres E, Jumeaux C, Sherwood JM, Stamer WD, Zelikin AN, Overby DR, Stevens MM. Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma. Adv Mater. 2017 Apr;29(16).
Journal cover image

Published In

Adv Mater

DOI

EISSN

1521-4095

Publication Date

April 2017

Volume

29

Issue

16

Location

Germany

Related Subject Headings

  • Nitric Oxide
  • Nanoscience & Nanotechnology
  • Mice
  • Intraocular Pressure
  • Glaucoma
  • Biocatalysis
  • Aqueous Humor
  • Animals
  • 51 Physical sciences
  • 40 Engineering