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Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry.

Publication ,  Journal Article
Osho, AA; Hirji, SA; Castleberry, AW; Mulvihill, MS; Ganapathi, AM; Speicher, PJ; Yerokun, B; Snyder, LD; Davis, RD; Hartwig, MG
Published in: Clin Transplant
May 2017

BACKGROUND: Kidney transplantation has been advocated as a therapeutic option in lung recipients who develop end-stage renal disease (ESRD). This analysis outlines patterns of allograft survival following kidney transplantation in previous lung recipients (KAL). METHODS: Data from the UNOS lung and kidney transplantation registries (1987-2013) were cross-linked to identify lung recipients who were subsequently listed for and/or underwent kidney transplantation. Time-dependent Cox models compared the survival rates in KAL patients with those waitlisted for renal transplantation who never received kidneys. Survival analyses compared outcomes between KAL patients and risk-matched recipients of primary, kidney-only transplantation with no history of lung transplantation (KTx). RESULTS: A total of 270 lung recipients subsequently underwent kidney transplantation (KAL). Regression models demonstrated a lower risk of post-listing mortality for KAL patients compared with 346 lung recipients on the kidney waitlist who never received kidneys (P<.05). Comparisons between matched KAL and KTx patients demonstrated significantly increased risk of death and graft loss (P<.05), but not death-censored graft loss, for KAL patients (P = .86). CONCLUSIONS: KAL patients enjoy a significant survival benefit compared with waitlisted lung recipients who do not receive kidneys. However, KAL patients do poorly compared with KTx patients. Decisions about KAL transplantation must be made on a case-by-case basis considering patient and donor factors.

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Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

May 2017

Volume

31

Issue

5

Location

Denmark

Related Subject Headings

  • Transplantation, Homologous
  • Transplant Recipients
  • Survival Rate
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Registries
  • Prognosis
  • Middle Aged
  • Male
 

Citation

APA
Chicago
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MLA
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Osho, A. A., Hirji, S. A., Castleberry, A. W., Mulvihill, M. S., Ganapathi, A. M., Speicher, P. J., … Hartwig, M. G. (2017). Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry. Clin Transplant, 31(5). https://doi.org/10.1111/ctr.12953
Osho, Asishana A., Sameer A. Hirji, Anthony W. Castleberry, Michael S. Mulvihill, Asvin M. Ganapathi, Paul J. Speicher, Babatunde Yerokun, Laurie D. Snyder, Robert D. Davis, and Mathew G. Hartwig. “Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry.Clin Transplant 31, no. 5 (May 2017). https://doi.org/10.1111/ctr.12953.
Osho AA, Hirji SA, Castleberry AW, Mulvihill MS, Ganapathi AM, Speicher PJ, et al. Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry. Clin Transplant. 2017 May;31(5).
Osho, Asishana A., et al. “Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry.Clin Transplant, vol. 31, no. 5, May 2017. Pubmed, doi:10.1111/ctr.12953.
Osho AA, Hirji SA, Castleberry AW, Mulvihill MS, Ganapathi AM, Speicher PJ, Yerokun B, Snyder LD, Davis RD, Hartwig MG. Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry. Clin Transplant. 2017 May;31(5).

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

May 2017

Volume

31

Issue

5

Location

Denmark

Related Subject Headings

  • Transplantation, Homologous
  • Transplant Recipients
  • Survival Rate
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Registries
  • Prognosis
  • Middle Aged
  • Male