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Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.

Publication ,  Journal Article
Grassmann, F; Kiel, C; Zimmermann, ME; Gorski, M; Grassmann, V; Stark, K; International AMD Genomics Consortium (IAMDGC); Heid, IM; Weber, BHF
Published in: Genome Med
March 27, 2017

BACKGROUND: Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits. METHODS: For each of 60 complex diseases/traits with publicly available genome-wide significant association data, the lead genetic variant per independent locus was extracted and a genetic score was calculated for each disease/trait as the weighted sum of risk alleles. The association with AMD was estimated based on 16,144 AMD cases and 17,832 controls using logistic regression. RESULTS: Of the respective disease/trait variance, the 60 genetic scores explained on average 4.8% (0.27-20.69%) and 16 of them were found to be significantly associated with AMD (Q-values < 0.01, p values from < 1.0 × 10-16 to 1.9 × 10-3). Notably, an increased risk for AMD was associated with reduced risk for cardiovascular diseases, increased risk for autoimmune diseases, higher HDL and lower LDL levels in serum, lower bone-mineral density as well as an increased risk for skin cancer. By restricting the analysis to 1824 variants initially used to compute the 60 genetic scores, we identified 28 novel AMD risk variants (Q-values < 0.01, p values from 1.1 × 10-7 to 3.0 × 10-4), known to be involved in cardiovascular disorders, lipid metabolism, autoimmune diseases, anthropomorphic traits, ocular disorders, and neurological diseases. The latter variants represent 20 novel AMD-associated, pleiotropic loci. Genes in the novel loci reinforce previous findings strongly implicating the complement system in AMD pathogenesis. CONCLUSIONS: We demonstrate a substantial overlap of the genetics of several complex diseases/traits with AMD and provide statistically significant evidence for an additional 20 loci associated with AMD. This highlights the possibility that so far unrelated pathologies may have disease pathways in common.

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Published In

Genome Med

DOI

EISSN

1756-994X

Publication Date

March 27, 2017

Volume

9

Issue

1

Start / End Page

29

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Male
  • Macular Degeneration
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Pleiotropy
  • Genetic Loci
  • Female
  • 3105 Genetics
 

Citation

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Grassmann, F., Kiel, C., Zimmermann, M. E., Gorski, M., Grassmann, V., Stark, K., … Weber, B. H. F. (2017). Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Med, 9(1), 29. https://doi.org/10.1186/s13073-017-0418-0
Grassmann, Felix, Christina Kiel, Martina E. Zimmermann, Mathias Gorski, Veronika Grassmann, Klaus Stark, International AMD Genomics Consortium (IAMDGC), Iris M. Heid, and Bernhard H. F. Weber. “Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.Genome Med 9, no. 1 (March 27, 2017): 29. https://doi.org/10.1186/s13073-017-0418-0.
Grassmann F, Kiel C, Zimmermann ME, Gorski M, Grassmann V, Stark K, et al. Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Med. 2017 Mar 27;9(1):29.
Grassmann, Felix, et al. “Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.Genome Med, vol. 9, no. 1, Mar. 2017, p. 29. Pubmed, doi:10.1186/s13073-017-0418-0.
Grassmann F, Kiel C, Zimmermann ME, Gorski M, Grassmann V, Stark K, International AMD Genomics Consortium (IAMDGC), Heid IM, Weber BHF. Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Med. 2017 Mar 27;9(1):29.
Journal cover image

Published In

Genome Med

DOI

EISSN

1756-994X

Publication Date

March 27, 2017

Volume

9

Issue

1

Start / End Page

29

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Male
  • Macular Degeneration
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Pleiotropy
  • Genetic Loci
  • Female
  • 3105 Genetics