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Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men.

Publication ,  Journal Article
Epplein, M; Zheng, W; Xiang, Y-B; Peek, RM; Li, H; Correa, P; Gao, J; Michel, A; Pawlita, M; Cai, Q; Shu, X-O
Published in: Cancer Epidemiol Biomarkers Prev
December 2012

BACKGROUND: Helicobacter pylori is the leading risk factor for gastric cancer, yet only a fraction of infected individuals ever develop neoplasia. METHODS: To identify potential predictive biomarkers, we assessed the association of 15 antibodies to H. pylori proteins and gastric cancer in a nested case-control study. Blood levels of antibodies were assessed using multiplex serology for 226 incident cases and 451 matched controls from the Shanghai Men's Health Study. ORs and 95% confidence intervals (CI) were calculated using conditional logistic regression. RESULTS: Seropositivity to four (Omp, HP0305, HyuA, and HpaA) proteins was associated with a 1.5- to 3-fold increased risk for gastric cancer. When excluding cases diagnosed within 2 years of study enrollment, seropositivity to two additional proteins (CagA and VacA) showed significant associations with risk. Compared with individuals with three or fewer seropositive results to the six virulent proteins identified in this population, individuals with four to five seropositive results were at a 2-fold increased risk (OR, 2.08; 95% CI, 1.31-3.30) and individuals seropositive to all six proteins had a 3.5-fold increase in risk (OR, 3.49; 95% CI, 2.00-6.11) for gastric cancer. Among individuals diagnosed at least 2 years after study enrollment, these associations were even stronger (ORs, 2.79 and 4.16, respectively). CONCLUSIONS: Increasing number of seropositives to six H. pylori proteins may be a risk marker for distal gastric cancer in China. IMPACT: In a population with a 90% prevalence of CagA-positive H. pylori infection, assessment of additional virulent H. pylori proteins might better identify individuals at high risk for gastric cancer.

Duke Scholars

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

December 2012

Volume

21

Issue

12

Start / End Page

2185 / 2192

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Epidemiology
  • Cohort Studies
 

Citation

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Epplein, M., Zheng, W., Xiang, Y.-B., Peek, R. M., Li, H., Correa, P., … Shu, X.-O. (2012). Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men. Cancer Epidemiol Biomarkers Prev, 21(12), 2185–2192. https://doi.org/10.1158/1055-9965.EPI-12-0792-T
Epplein, Meira, Wei Zheng, Yong-Bing Xiang, Richard M. Peek, Honglan Li, Pelayo Correa, Jing Gao, et al. “Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men.Cancer Epidemiol Biomarkers Prev 21, no. 12 (December 2012): 2185–92. https://doi.org/10.1158/1055-9965.EPI-12-0792-T.
Epplein M, Zheng W, Xiang Y-B, Peek RM, Li H, Correa P, et al. Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men. Cancer Epidemiol Biomarkers Prev. 2012 Dec;21(12):2185–92.
Epplein, Meira, et al. “Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men.Cancer Epidemiol Biomarkers Prev, vol. 21, no. 12, Dec. 2012, pp. 2185–92. Pubmed, doi:10.1158/1055-9965.EPI-12-0792-T.
Epplein M, Zheng W, Xiang Y-B, Peek RM, Li H, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Shu X-O. Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men. Cancer Epidemiol Biomarkers Prev. 2012 Dec;21(12):2185–2192.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

December 2012

Volume

21

Issue

12

Start / End Page

2185 / 2192

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Epidemiology
  • Cohort Studies