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Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.

Publication ,  Journal Article
Epplein, M; Reed, SD; Voigt, LF; Newton, KM; Holt, VL; Weiss, NS
Published in: Am J Epidemiol
September 15, 2008

The authors sought to test the hypothesis that characteristics and exposures which influence the balance of estrogen and progesterone bear on the incidence of endometrial hyperplasia (EH), a noninvasive proliferation of the lining of the uterus. Cases included all female members of Group Health (Washington State) who were diagnosed with complex EH or EH with atypia during the period 1985-2003 and whose diagnoses were confirmed in a pathology review (n = 446). Controls were selected randomly from Group Health membership files and were matched to the cases by age and enrollment status at the reference date. An increased risk of EH was associated with increasing body mass index and nulliparity. There was a suggestion of a decreased risk of EH with atypia among current smokers. No association with diabetes or hypertension was found. The risk factors observed to be associated with EH in this study are similar to those associated with endometrial cancer. Whether these risk factors predispose women to cancer simply by increasing EH incidence or continue to augment cancer risk even after EH is present is currently unknown.

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Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

September 15, 2008

Volume

168

Issue

6

Start / End Page

563 / 570

Location

United States

Related Subject Headings

  • Washington
  • Smoking
  • Receptors, Estrogen
  • Pregnancy
  • Parity
  • Obesity
  • Middle Aged
  • Medical Records Systems, Computerized
  • Incidence
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Epplein, M., Reed, S. D., Voigt, L. F., Newton, K. M., Holt, V. L., & Weiss, N. S. (2008). Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am J Epidemiol, 168(6), 563–570. https://doi.org/10.1093/aje/kwn168
Epplein, Meira, Susan D. Reed, Lynda F. Voigt, Katherine M. Newton, Victoria L. Holt, and Noel S. Weiss. “Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.Am J Epidemiol 168, no. 6 (September 15, 2008): 563–70. https://doi.org/10.1093/aje/kwn168.
Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, Weiss NS. Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am J Epidemiol. 2008 Sep 15;168(6):563–70.
Epplein, Meira, et al. “Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.Am J Epidemiol, vol. 168, no. 6, Sept. 2008, pp. 563–70. Pubmed, doi:10.1093/aje/kwn168.
Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, Weiss NS. Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am J Epidemiol. 2008 Sep 15;168(6):563–570.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

September 15, 2008

Volume

168

Issue

6

Start / End Page

563 / 570

Location

United States

Related Subject Headings

  • Washington
  • Smoking
  • Receptors, Estrogen
  • Pregnancy
  • Parity
  • Obesity
  • Middle Aged
  • Medical Records Systems, Computerized
  • Incidence
  • Humans