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Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement.

Publication ,  Journal Article
Jiranek, WA; Hanssen, AD; Greenwald, AS
Published in: J Bone Joint Surg Am
November 2006

Use of antibiotic-loaded bone cement for prophylaxis against infection is not indicated for patients not at high risk for infection who are undergoing routine primary or revision joint replacement with cement. The mechanical and elution properties of commercially available premixed antibiotic-loaded bone-cement products are superior to those of hand-mixed preparations. Use of commercially available antibiotic-loaded bone-cement products has been cleared by the United States Food and Drug Administration only for use in the second stage of a two-stage total joint revision following removal of the original prosthesis and elimination of active periprosthetic infection. Use of antibiotic-loaded bone cement for prophylaxis against infection in the second stage of a two-stage total joint revision involves low doses of antibiotics. Active infection cannot be treated with commercially available antibiotic-loaded bone cement as such treatment requires higher doses of antibiotics.

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Published In

J Bone Joint Surg Am

DOI

ISSN

0021-9355

Publication Date

November 2006

Volume

88

Issue

11

Start / End Page

2487 / 2500

Location

United States

Related Subject Headings

  • Surgical Wound Infection
  • Prosthesis-Related Infections
  • Pharmaceutical Vehicles
  • Orthopedics
  • Humans
  • Drug Resistance, Microbial
  • Drug Hypersensitivity
  • Bone Cements
  • Bacterial Infections
  • Arthroplasty, Replacement
 

Citation

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Jiranek, W. A., Hanssen, A. D., & Greenwald, A. S. (2006). Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am, 88(11), 2487–2500. https://doi.org/10.2106/JBJS.E.01126
Jiranek, William A., Arlen D. Hanssen, and A Seth Greenwald. “Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement.J Bone Joint Surg Am 88, no. 11 (November 2006): 2487–2500. https://doi.org/10.2106/JBJS.E.01126.
Jiranek WA, Hanssen AD, Greenwald AS. Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am. 2006 Nov;88(11):2487–500.
Jiranek, William A., et al. “Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement.J Bone Joint Surg Am, vol. 88, no. 11, Nov. 2006, pp. 2487–500. Pubmed, doi:10.2106/JBJS.E.01126.
Jiranek WA, Hanssen AD, Greenwald AS. Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am. 2006 Nov;88(11):2487–2500.
Journal cover image

Published In

J Bone Joint Surg Am

DOI

ISSN

0021-9355

Publication Date

November 2006

Volume

88

Issue

11

Start / End Page

2487 / 2500

Location

United States

Related Subject Headings

  • Surgical Wound Infection
  • Prosthesis-Related Infections
  • Pharmaceutical Vehicles
  • Orthopedics
  • Humans
  • Drug Resistance, Microbial
  • Drug Hypersensitivity
  • Bone Cements
  • Bacterial Infections
  • Arthroplasty, Replacement