Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement.
Use of antibiotic-loaded bone cement for prophylaxis against infection is not indicated for patients not at high risk for infection who are undergoing routine primary or revision joint replacement with cement. The mechanical and elution properties of commercially available premixed antibiotic-loaded bone-cement products are superior to those of hand-mixed preparations. Use of commercially available antibiotic-loaded bone-cement products has been cleared by the United States Food and Drug Administration only for use in the second stage of a two-stage total joint revision following removal of the original prosthesis and elimination of active periprosthetic infection. Use of antibiotic-loaded bone cement for prophylaxis against infection in the second stage of a two-stage total joint revision involves low doses of antibiotics. Active infection cannot be treated with commercially available antibiotic-loaded bone cement as such treatment requires higher doses of antibiotics.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Surgical Wound Infection
- Prosthesis-Related Infections
- Pharmaceutical Vehicles
- Orthopedics
- Humans
- Drug Resistance, Microbial
- Drug Hypersensitivity
- Bone Cements
- Bacterial Infections
- Arthroplasty, Replacement
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Surgical Wound Infection
- Prosthesis-Related Infections
- Pharmaceutical Vehicles
- Orthopedics
- Humans
- Drug Resistance, Microbial
- Drug Hypersensitivity
- Bone Cements
- Bacterial Infections
- Arthroplasty, Replacement