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Macrophage activation results in bone resorption.

Publication ,  Journal Article
Lassus, J; Salo, J; Jiranek, WA; Santavirta, S; Nevalainen, J; Matucci-Cerinic, M; Horák, P; Konttinen, Y
Published in: Clin Orthop Relat Res
July 1998

Monocytes or macrophages from important accessory cells in the regulation of bone metabolism and destruction. Cells of the mononuclear phagocyte lineage form the precursor cells of the osteoclasts. Soluble products produced by activated macrophages regulate progenitor cell proliferation, recruitment, differentiation, and activity of osteoblasts and osteoclasts. After osteoclasts are removed from the resorption site, macrophages process bone surfaces and create a cement line before osteoblasts enter to form new bone. Although osteolysis associated with normal bone remodeling is seen as an osteoclast driven process, it may be that in chronic inflammation macrophage activation and vascular derangements lead to low pH, local bone demineralization (acid attack), and H+ mediated stimulation of the primary afferent nociceptive nerve fibers (bone pain). Osteoclasts are not able to attach to demineralized bone or to osteoid surfaces. However, if macrophages degrade the demineralized organic bone matrix, chemotactic factors and attachment sites for osteoclasts are produced. In such a scenario, the osteoclast-osteoblast mediated activation, resorption, and formation cycle would be secondarily activated. Such events may play a role in the most common orthopaedic problem related to macrophage activation, aseptic loosening of orthopaedic joint implants, which is secondary to a chronic foreign body reaction and to micromovement.

Duke Scholars

Published In

Clin Orthop Relat Res

ISSN

0009-921X

Publication Date

July 1998

Issue

352

Start / End Page

7 / 15

Location

United States

Related Subject Headings

  • Prosthesis Failure
  • Osteoclasts
  • Orthopedics
  • Macrophage Activation
  • Humans
  • Hip Prosthesis
  • Bone Resorption
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Lassus, J., Salo, J., Jiranek, W. A., Santavirta, S., Nevalainen, J., Matucci-Cerinic, M., … Konttinen, Y. (1998). Macrophage activation results in bone resorption. Clin Orthop Relat Res, (352), 7–15.
Lassus, J., J. Salo, W. A. Jiranek, S. Santavirta, J. Nevalainen, M. Matucci-Cerinic, P. Horák, and Y. Konttinen. “Macrophage activation results in bone resorption.Clin Orthop Relat Res, no. 352 (July 1998): 7–15.
Lassus J, Salo J, Jiranek WA, Santavirta S, Nevalainen J, Matucci-Cerinic M, et al. Macrophage activation results in bone resorption. Clin Orthop Relat Res. 1998 Jul;(352):7–15.
Lassus, J., et al. “Macrophage activation results in bone resorption.Clin Orthop Relat Res, no. 352, July 1998, pp. 7–15.
Lassus J, Salo J, Jiranek WA, Santavirta S, Nevalainen J, Matucci-Cerinic M, Horák P, Konttinen Y. Macrophage activation results in bone resorption. Clin Orthop Relat Res. 1998 Jul;(352):7–15.
Journal cover image

Published In

Clin Orthop Relat Res

ISSN

0009-921X

Publication Date

July 1998

Issue

352

Start / End Page

7 / 15

Location

United States

Related Subject Headings

  • Prosthesis Failure
  • Osteoclasts
  • Orthopedics
  • Macrophage Activation
  • Humans
  • Hip Prosthesis
  • Bone Resorption
  • 3202 Clinical sciences
  • 1103 Clinical Sciences