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Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release.

Publication ,  Journal Article
Han, W; Chilkoti, A; López, GP
Published in: Nanoscale
May 2017

The discovery of biomimetic polypeptides that enable the biomineralization of synthetic and biosynthetic materials has resulted in the development of hybrid materials that incorporate inorganic components for potential application in drug delivery, enzyme immobilization, and surface modification. Here, we describe an approach that uses micellar assemblies of an elastin-like polypeptide (ELP) modified with silica-promoting sequences and drug conjugates that are subsequently encapsulated within a silica matrix. Incorporation of a lysine-rich tag derived from the silaffin R5 peptide into the N-terminus of a hydrophilic ELP that self-assembles upon conjugation of hydrophobic molecules at the C-terminus results in the formation of spherical micelles with a conjugated drug embedded in the core and a corona that is decorated with the silaffin peptide. These micelles serve as the building blocks for the polycondensation of silica into uniform, hybrid polypeptide-silica nanoparticles. We demonstrate proof-of-concept examples using a model hydrophobic small molecule and doxorobucin, a small molecule chemotherapeutic, and further show pH-dependent doxorubicin release from the hybrid nanoparticles.

Duke Scholars

Published In

Nanoscale

DOI

EISSN

2040-3372

ISSN

2040-3364

Publication Date

May 2017

Volume

9

Issue

18

Start / End Page

6178 / 6186

Related Subject Headings

  • Silicon Dioxide
  • Peptides
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Elastin
  • Drug Liberation
  • Doxorubicin
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Han, W., Chilkoti, A., & López, G. P. (2017). Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release. Nanoscale, 9(18), 6178–6186. https://doi.org/10.1039/c7nr00172j
Han, Wei, Ashutosh Chilkoti, and Gabriel P. López. “Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release.Nanoscale 9, no. 18 (May 2017): 6178–86. https://doi.org/10.1039/c7nr00172j.
Han W, Chilkoti A, López GP. Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release. Nanoscale. 2017 May;9(18):6178–86.
Han, Wei, et al. “Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release.Nanoscale, vol. 9, no. 18, May 2017, pp. 6178–86. Epmc, doi:10.1039/c7nr00172j.
Han W, Chilkoti A, López GP. Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release. Nanoscale. 2017 May;9(18):6178–6186.
Journal cover image

Published In

Nanoscale

DOI

EISSN

2040-3372

ISSN

2040-3364

Publication Date

May 2017

Volume

9

Issue

18

Start / End Page

6178 / 6186

Related Subject Headings

  • Silicon Dioxide
  • Peptides
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Elastin
  • Drug Liberation
  • Doxorubicin
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences