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Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study.

Publication ,  Journal Article
Heckbert, SR; Wiggins, KL; Blackshear, C; Yang, Y; Ding, J; Liu, J; McKnight, B; Alonso, A; Austin, TR; Benjamin, EJ; Curtis, LH; Correa, A ...
Published in: Obesity (Silver Spring)
June 2017

OBJECTIVE: To determine whether greater pericardial fat volume would be associated with increased risk of incident atrial fibrillation (AF). METHODS: In the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study, pericardial fat volume was quantified by computed tomography. Incident AF was identified from discharge diagnosis codes, study electrocardiograms, and Medicare claims. RESULTS: Among 7,991 participants, 40% were African American, 32% white, 18% Hispanic, and 10% Chinese American; mean age was 62 years; 55% were women. During an average of 10.0 years of follow-up in the Multi-Ethnic Study of Atherosclerosis and 4.5 years in the Jackson Heart Study, 756 incident AF cases were identified. After adjustment for age, sex, study, race/ethnicity, height, glucose status, systolic blood pressure, treated hypertension, and BMI, greater pericardial fat volume was associated with higher AF risk in Hispanics (hazard ratio 1.24 per SD, 95% confidence interval 1.05-1.46) but not overall (hazard ratio 1.06, 95% confidence interval 0.97-1.15). In mediation analysis, pericardial fat volume partially mediated the association of BMI with incident AF in Hispanics. CONCLUSIONS: After adjustment for BMI, greater pericardial fat volume was associated with incident AF in Hispanics but not overall. Additional research is needed on the mechanisms by which pericardial fat volume is related to increased AF risk and possible differences by race/ethnicity.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

June 2017

Volume

25

Issue

6

Start / End Page

1115 / 1121

Location

United States

Related Subject Headings

  • Pericardium
  • Middle Aged
  • Male
  • Humans
  • Female
  • Ethnicity
  • Endocrinology & Metabolism
  • Cardiovascular Diseases
  • Atrial Fibrillation
  • Atherosclerosis
 

Citation

APA
Chicago
ICMJE
MLA
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Heckbert, S. R., Wiggins, K. L., Blackshear, C., Yang, Y., Ding, J., Liu, J., … Correa, A. (2017). Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study. Obesity (Silver Spring), 25(6), 1115–1121. https://doi.org/10.1002/oby.21835
Heckbert, Susan R., Kerri L. Wiggins, Chad Blackshear, Yi Yang, Jingzhong Ding, Jiankang Liu, Barbara McKnight, et al. “Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study.Obesity (Silver Spring) 25, no. 6 (June 2017): 1115–21. https://doi.org/10.1002/oby.21835.
Heckbert SR, Wiggins KL, Blackshear C, Yang Y, Ding J, Liu J, et al. Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study. Obesity (Silver Spring). 2017 Jun;25(6):1115–21.
Heckbert, Susan R., et al. “Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study.Obesity (Silver Spring), vol. 25, no. 6, June 2017, pp. 1115–21. Pubmed, doi:10.1002/oby.21835.
Heckbert SR, Wiggins KL, Blackshear C, Yang Y, Ding J, Liu J, McKnight B, Alonso A, Austin TR, Benjamin EJ, Curtis LH, Sotoodehnia N, Correa A. Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study. Obesity (Silver Spring). 2017 Jun;25(6):1115–1121.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

June 2017

Volume

25

Issue

6

Start / End Page

1115 / 1121

Location

United States

Related Subject Headings

  • Pericardium
  • Middle Aged
  • Male
  • Humans
  • Female
  • Ethnicity
  • Endocrinology & Metabolism
  • Cardiovascular Diseases
  • Atrial Fibrillation
  • Atherosclerosis