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Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife.

Publication ,  Journal Article
Williams, MJA; Milne, BJ; Ambler, A; Theodore, R; Ramrakha, S; Caspi, A; Moffitt, TE; Poulton, R
Published in: International journal of obesity (2005)
September 2017

Endothelial dysfunction predicts mortality but it is unknown whether childhood obesity predicts adult endothelial dysfunction. The aim of this study was to determine whether anthropometric indices of body fat in childhood, adolescence and early midlife are associated with endothelial dysfunction in early midlife.Participants belonged to a representative birth cohort of 1037 individuals born in Dunedin, New Zealand in 1972 and 1973 and followed to age 38 years, with 95% retention (the Dunedin Multidisciplinary Health and Development Study). We assessed anthropometric indices of obesity at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, 26, 32 and 38 years. We tested associations between endothelial function assessed by peripheral arterial tonometry (PAT) at age 38 and; age 38 cardiovascular risk factors; age 3 body mass index (BMI); and four BMI trajectory groups from childhood to early midlife.Early midlife endothelial dysfunction was associated with BMI, large waist circumference, low high-density lipoprotein cholesterol, low cardiorespiratory fitness and increased high-sensitivity C-reactive protein. After adjustment for sex and childhood socioeconomic status, 3-year-olds with BMI 1 s.d. above the mean had Framingham-reactive hyperemia index (F-RHI) ratios that were 0.10 below those with normal BMI (β=-0.10, 95% confidence interval (CI) -0.17 to -0.03, P=0.007) at age 38. Cohort members in the 'overweight', 'obese' and 'morbidly obese' trajectories had F-RHI ratios that were 0.08 (β=-0.08, 95% CI -0.14 to -0.03, P=0.003), 0.13 (β=-0.13, 95% CI -0.21 to -0.06, P<0.001) and 0.17 (β=-0.17, 95% CI -0.33 to -0.01, P=0.033), respectively, below age-peers in the 'normal' trajectory.Childhood BMI and the trajectories of BMI from childhood to early midlife predict endothelial dysfunction evaluated by PAT in early midlife.

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Published In

International journal of obesity (2005)

DOI

EISSN

1476-5497

ISSN

0307-0565

Publication Date

September 2017

Volume

41

Issue

9

Start / End Page

1355 / 1360

Related Subject Headings

  • Waist Circumference
  • Risk Factors
  • Pediatric Obesity
  • New Zealand
  • Manometry
  • Male
  • Longitudinal Studies
  • Lipoproteins, HDL
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Williams, M. J. A., Milne, B. J., Ambler, A., Theodore, R., Ramrakha, S., Caspi, A., … Poulton, R. (2017). Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. International Journal of Obesity (2005), 41(9), 1355–1360. https://doi.org/10.1038/ijo.2017.108
Williams, M. J. A., B. J. Milne, A. Ambler, R. Theodore, S. Ramrakha, A. Caspi, T. E. Moffitt, and R. Poulton. “Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife.International Journal of Obesity (2005) 41, no. 9 (September 2017): 1355–60. https://doi.org/10.1038/ijo.2017.108.
Williams MJA, Milne BJ, Ambler A, Theodore R, Ramrakha S, Caspi A, et al. Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. International journal of obesity (2005). 2017 Sep;41(9):1355–60.
Williams, M. J. A., et al. “Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife.International Journal of Obesity (2005), vol. 41, no. 9, Sept. 2017, pp. 1355–60. Epmc, doi:10.1038/ijo.2017.108.
Williams MJA, Milne BJ, Ambler A, Theodore R, Ramrakha S, Caspi A, Moffitt TE, Poulton R. Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. International journal of obesity (2005). 2017 Sep;41(9):1355–1360.

Published In

International journal of obesity (2005)

DOI

EISSN

1476-5497

ISSN

0307-0565

Publication Date

September 2017

Volume

41

Issue

9

Start / End Page

1355 / 1360

Related Subject Headings

  • Waist Circumference
  • Risk Factors
  • Pediatric Obesity
  • New Zealand
  • Manometry
  • Male
  • Longitudinal Studies
  • Lipoproteins, HDL
  • Humans
  • Female