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Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility.

Publication ,  Journal Article
Li, W; Liu, P; Lu, H; Strouse, JJ; van Zijl, PCM; Qin, Q
Published in: Magn Reson Med
June 2017

PURPOSE: To develop a fast protocol for measuring T1 values in the internal carotid artery (ICA), to validate this technique with in vitro measurements, and to evaluate its reproducibility. METHODS: A modified Look-Locker sequence was optimized to enable rapid determination of T1 in the ICA at 3T. T1 values from the ICA were compared with in vitro measurements on individually sampled venous blood oxygenated to arterial levels. A test-retest reproducibility study was also conducted. RESULTS: The group-averaged arterial blood T1 value was 1908 ± 77 ms for six women (hematocrit = 0.39 ± 0.03) and 1785 ± 55 ms for seven men (hematocrit = 0.45 ± 0.02), which is 100-200 ms longer than the widely adopted value obtained from bovine blood experiments. The arterial T1 value per subject correlated significantly with individual hematocrit values. The intrasession and intersession coefficients of variation were 1.1% and 2.1%, respectively, indicating good precision and reproducibility of our method. Reasonable agreement was observed between the in vivo and in vitro results with a correlation coefficient of 0.78. CONCLUSION: The proposed method can provide fast arterial T1 measurement on individual subjects. When not performing such a subject-specific measurement, we recommend the use of 1908 ms and 1785 ms for healthy women and men, respectively, or 1841 ms for adults in general. Magn Reson Med 77:2296-2302, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

June 2017

Volume

77

Issue

6

Start / End Page

2296 / 2302

Location

United States

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Angiography
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Humans
  • Female
 

Citation

APA
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Li, W., Liu, P., Lu, H., Strouse, J. J., van Zijl, P. C. M., & Qin, Q. (2017). Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility. Magn Reson Med, 77(6), 2296–2302. https://doi.org/10.1002/mrm.26325
Li, Wenbo, Peiying Liu, Hanzhang Lu, John J. Strouse, Peter C. M. van Zijl, and Qin Qin. “Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility.Magn Reson Med 77, no. 6 (June 2017): 2296–2302. https://doi.org/10.1002/mrm.26325.
Li W, Liu P, Lu H, Strouse JJ, van Zijl PCM, Qin Q. Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility. Magn Reson Med. 2017 Jun;77(6):2296–302.
Li, Wenbo, et al. “Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility.Magn Reson Med, vol. 77, no. 6, June 2017, pp. 2296–302. Pubmed, doi:10.1002/mrm.26325.
Li W, Liu P, Lu H, Strouse JJ, van Zijl PCM, Qin Q. Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility. Magn Reson Med. 2017 Jun;77(6):2296–2302.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

June 2017

Volume

77

Issue

6

Start / End Page

2296 / 2302

Location

United States

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Angiography
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Humans
  • Female