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Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies.

Publication ,  Journal Article
Emerging Risk Factors Collaboration, ; Wormser, D; Kaptoge, S; Di Angelantonio, E; Wood, AM; Pennells, L; Thompson, A; Sarwar, N; Kizer, JR ...
Published in: Lancet
March 26, 2011

BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease. METHODS: We used individual records from 58 cohorts to calculate hazard ratios (HRs) per 1 SD higher baseline values (4.56 kg/m(2) higher BMI, 12.6 cm higher waist circumference, and 0.083 higher waist-to-hip ratio) and measures of risk discrimination and reclassification. Serial adiposity assessments were used to calculate regression dilution ratios. RESULTS: Individual records were available for 221,934 people in 17 countries (14,297 incident cardiovascular disease outcomes; 1.87 million person-years at risk). Serial adiposity assessments were made in up to 63,821 people (mean interval 5.7 years [SD 3.9]). In people with BMI of 20 kg/m(2) or higher, HRs for cardiovascular disease were 1.23 (95% CI 1.17-1.29) with BMI, 1.27 (1.20-1.33) with waist circumference, and 1.25 (1.19-1.31) with waist-to-hip ratio, after adjustment for age, sex, and smoking status. After further adjustment for baseline systolic blood pressure, history of diabetes, and total and HDL cholesterol, corresponding HRs were 1.07 (1.03-1.11) with BMI, 1.10 (1.05-1.14) with waist circumference, and 1.12 (1.08-1.15) with waist-to-hip ratio. Addition of information on BMI, waist circumference, or waist-to-hip ratio to a cardiovascular disease risk prediction model containing conventional risk factors did not importantly improve risk discrimination (C-index changes of -0.0001, -0.0001, and 0.0008, respectively), nor classification of participants to categories of predicted 10-year risk (net reclassification improvement -0.19%, -0.05%, and -0.05%, respectively). Findings were similar when adiposity measures were considered in combination. Reproducibility was greater for BMI (regression dilution ratio 0.95, 95% CI 0.93-0.97) than for waist circumference (0.86, 0.83-0.89) or waist-to-hip ratio (0.63, 0.57-0.70). INTERPRETATION: BMI, waist circumference, and waist-to-hip ratio, whether assessed singly or in combination, do not importantly improve cardiovascular disease risk prediction in people in developed countries when additional information is available for systolic blood pressure, history of diabetes, and lipids. FUNDING: British Heart Foundation and UK Medical Research Council.

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Published In

Lancet

DOI

EISSN

1474-547X

Publication Date

March 26, 2011

Volume

377

Issue

9771

Start / End Page

1085 / 1095

Location

England

Related Subject Headings

  • Waist-Hip Ratio
  • Waist Circumference
  • Systole
  • Smoking
  • Sex Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models
  • Obesity, Abdominal
  • Middle Aged
 

Citation

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Emerging Risk Factors Collaboration, ., Wormser, D., Kaptoge, S., Di Angelantonio, E., Wood, A. M., Pennells, L., … Danesh, J. (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet, 377(9771), 1085–1095. https://doi.org/10.1016/S0140-6736(11)60105-0
Emerging Risk Factors Collaboration, John, David Wormser, Stephen Kaptoge, Emanuele Di Angelantonio, Angela M. Wood, Lisa Pennells, Alex Thompson, et al. “Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies.Lancet 377, no. 9771 (March 26, 2011): 1085–95. https://doi.org/10.1016/S0140-6736(11)60105-0.
Emerging Risk Factors Collaboration, Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet. 2011 Mar 26;377(9771):1085–95.
Emerging Risk Factors Collaboration, John, et al. “Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies.Lancet, vol. 377, no. 9771, Mar. 2011, pp. 1085–95. Pubmed, doi:10.1016/S0140-6736(11)60105-0.
Emerging Risk Factors Collaboration, Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, Thompson A, Sarwar N, Kizer JR, Lawlor DA, Nordestgaard BG, Ridker P, Salomaa V, Stevens J, Woodward M, Sattar N, Collins R, Thompson SG, Whitlock G, Danesh J. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet. 2011 Mar 26;377(9771):1085–1095.
Journal cover image

Published In

Lancet

DOI

EISSN

1474-547X

Publication Date

March 26, 2011

Volume

377

Issue

9771

Start / End Page

1085 / 1095

Location

England

Related Subject Headings

  • Waist-Hip Ratio
  • Waist Circumference
  • Systole
  • Smoking
  • Sex Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models
  • Obesity, Abdominal
  • Middle Aged