Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

The extracellular matrix protein agrin promotes heart regeneration in mice.

Publication ,  Journal Article
Bassat, E; Mutlak, YE; Genzelinakh, A; Shadrin, IY; Baruch Umansky, K; Yifa, O; Kain, D; Rajchman, D; Leach, J; Riabov Bassat, D; Udi, Y ...
Published in: Nature
July 2017

The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte growth and differentiation in mice. We identify agrin, a component of neonatal extracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts. In vitro, recombinant agrin promotes the division of cardiomyocytes that are derived from mouse and human induced pluripotent stem cells through a mechanism that involves the disassembly of the dystrophin-glycoprotein complex, and Yap- and ERK-mediated signalling. In vivo, a single administration of agrin promotes cardiac regeneration in adult mice after myocardial infarction, although the degree of cardiomyocyte proliferation observed in this model suggests that there are additional therapeutic mechanisms. Together, our results uncover a new inducer of mammalian heart regeneration and highlight fundamental roles of the extracellular matrix in cardiac repair.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nature

DOI

EISSN

1476-4687

ISSN

0028-0836

Publication Date

July 2017

Volume

547

Issue

7662

Start / End Page

179 / 184

Related Subject Headings

  • YAP-Signaling Proteins
  • Regeneration
  • Phosphoproteins
  • Myocytes, Cardiac
  • Myocardium
  • Myocardial Infarction
  • Mice
  • Heart
  • General Science & Technology
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bassat, E., Mutlak, Y. E., Genzelinakh, A., Shadrin, I. Y., Baruch Umansky, K., Yifa, O., … Tzahor, E. (2017). The extracellular matrix protein agrin promotes heart regeneration in mice. Nature, 547(7662), 179–184. https://doi.org/10.1038/nature22978
Bassat, Elad, Yara Eid Mutlak, Alex Genzelinakh, Ilya Y. Shadrin, Kfir Baruch Umansky, Oren Yifa, David Kain, et al. “The extracellular matrix protein agrin promotes heart regeneration in mice.Nature 547, no. 7662 (July 2017): 179–84. https://doi.org/10.1038/nature22978.
Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017 Jul;547(7662):179–84.
Bassat, Elad, et al. “The extracellular matrix protein agrin promotes heart regeneration in mice.Nature, vol. 547, no. 7662, July 2017, pp. 179–84. Epmc, doi:10.1038/nature22978.
Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017 Jul;547(7662):179–184.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

ISSN

0028-0836

Publication Date

July 2017

Volume

547

Issue

7662

Start / End Page

179 / 184

Related Subject Headings

  • YAP-Signaling Proteins
  • Regeneration
  • Phosphoproteins
  • Myocytes, Cardiac
  • Myocardium
  • Myocardial Infarction
  • Mice
  • Heart
  • General Science & Technology
  • Female