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Biomaterials from Nature for Advanced Devices and Therapies

Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering

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Bhattacharyya, J; Bellucci, JJ; Chilkoti, A
January 1, 2016

Elastin-Like Polypeptides (ELPs) have several interesting properties that are relevant to their use in biotechnology and medicine. ELPs have several interesting properties that are relevant to their use in biotechnology and medicine. First, ELPs exhibit reversible phase transition behavior, such that they are soluble below a particular temperature, their 'transition temperature' (Tt) or cloud point and are insoluble above it. In addition to their thermal responsiveness, ELPs have the advantage of being recombinant polypeptides that can be expressed at high yield in Escherichia coli (E. coli) and easily purified by their phase behavior by a nonchromatographic process. This also allows them to be produced as monodisperse polymers, polydispersity index of 1.0, that cannot be matched by any synthetic polymer. These properties of ELPs make them attractive for a variety of applications, including facilitating recombinant protein purification and delivery, improving the pharmacokinetics of small molecule and peptide drugs and providing scaffolds for tissue engineering.

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DOI

ISBN

9781118478059

Publication Date

January 1, 2016

Start / End Page

106 / 126
 

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Bhattacharyya, J., Bellucci, J. J., & Chilkoti, A. (2016). Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering. In Biomaterials from Nature for Advanced Devices and Therapies (pp. 106–126). https://doi.org/10.1002/9781119126218.ch7
Bhattacharyya, J., J. J. Bellucci, and A. Chilkoti. “Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering.” In Biomaterials from Nature for Advanced Devices and Therapies, 106–26, 2016. https://doi.org/10.1002/9781119126218.ch7.
Bhattacharyya J, Bellucci JJ, Chilkoti A. Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering. In: Biomaterials from Nature for Advanced Devices and Therapies. 2016. p. 106–26.
Bhattacharyya, J., et al. “Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering.” Biomaterials from Nature for Advanced Devices and Therapies, 2016, pp. 106–26. Scopus, doi:10.1002/9781119126218.ch7.
Bhattacharyya J, Bellucci JJ, Chilkoti A. Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering. Biomaterials from Nature for Advanced Devices and Therapies. 2016. p. 106–126.
Journal cover image

DOI

ISBN

9781118478059

Publication Date

January 1, 2016

Start / End Page

106 / 126