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Genetic Analysis of Complex Traits in Saccharomyces cerevisiae.

Publication ,  Journal Article
Ehrenreich, IM; Magwene, PM
Published in: Cold Spring Harbor protocols
June 2017

Defining the relationship between genotype and phenotype is a central challenge in biology. A powerful approach to this problem is to determine the genetic architecture and molecular basis of phenotypic differences among genetically diverse individuals. Saccharomyces cerevisiae is an important model system for such work. Current genetic mapping approaches for this species exploit high-throughput phenotyping and sequencing to facilitate the detection of a large fraction of the genomic loci that underlie trait variation among isolates. Once identified, several methods exist to determine the specific genes and genetic variants that underlie these loci and cause phenotypic variations. In this introduction, we provide a brief overview of research on complex traits in yeast and discuss different genetic mapping approaches applied to yeast studies.

Duke Scholars

Published In

Cold Spring Harbor protocols

DOI

EISSN

1559-6095

ISSN

1940-3402

Publication Date

June 2017

Volume

2017

Issue

6

Start / End Page

pdb.top077602

Related Subject Headings

  • Sequence Analysis, DNA
  • Saccharomyces cerevisiae
  • Multifactorial Inheritance
  • Molecular Biology
  • High-Throughput Screening Assays
  • Genetics, Microbial
  • Chromosome Mapping
  • 1103 Clinical Sciences
  • 0601 Biochemistry and Cell Biology
  • 0306 Physical Chemistry (incl. Structural)
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ehrenreich, I. M., & Magwene, P. M. (2017). Genetic Analysis of Complex Traits in Saccharomyces cerevisiae. Cold Spring Harbor Protocols, 2017(6), pdb.top077602. https://doi.org/10.1101/pdb.top077602
Ehrenreich, Ian M., and Paul M. Magwene. “Genetic Analysis of Complex Traits in Saccharomyces cerevisiae.Cold Spring Harbor Protocols 2017, no. 6 (June 2017): pdb.top077602. https://doi.org/10.1101/pdb.top077602.
Ehrenreich IM, Magwene PM. Genetic Analysis of Complex Traits in Saccharomyces cerevisiae. Cold Spring Harbor protocols. 2017 Jun;2017(6):pdb.top077602.
Ehrenreich, Ian M., and Paul M. Magwene. “Genetic Analysis of Complex Traits in Saccharomyces cerevisiae.Cold Spring Harbor Protocols, vol. 2017, no. 6, June 2017, p. pdb.top077602. Epmc, doi:10.1101/pdb.top077602.
Ehrenreich IM, Magwene PM. Genetic Analysis of Complex Traits in Saccharomyces cerevisiae. Cold Spring Harbor protocols. 2017 Jun;2017(6):pdb.top077602.

Published In

Cold Spring Harbor protocols

DOI

EISSN

1559-6095

ISSN

1940-3402

Publication Date

June 2017

Volume

2017

Issue

6

Start / End Page

pdb.top077602

Related Subject Headings

  • Sequence Analysis, DNA
  • Saccharomyces cerevisiae
  • Multifactorial Inheritance
  • Molecular Biology
  • High-Throughput Screening Assays
  • Genetics, Microbial
  • Chromosome Mapping
  • 1103 Clinical Sciences
  • 0601 Biochemistry and Cell Biology
  • 0306 Physical Chemistry (incl. Structural)