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The Utility of Expert Diagnosis in Surgical Neuropathology: Analysis of Consultations Reviewed at 5 National Comprehensive Cancer Network Institutions.

Publication ,  Journal Article
Bruner, JM; Louis, DN; McLendon, R; Rosenblum, MK; Archambault, WT; Most, S; Tihan, T
Published in: J Neuropathol Exp Neurol
March 1, 2017

The aim of this study was to characterize the type and degree of discrepancies between non-expert and expert diagnoses of CNS tumors to identify the value of consultations in surgical neuropathology. Neuropathology experts from 5 National Comprehensive Cancer Network (NCCN) member institutions participated in the review of 1281 consultations selected based on inclusion criteria. The consultation cases were re-reviewed at the NCCN headquarters to determine concordance with the original diagnoses. Among all consultations, 249 (19.4%) were submitted for expert diagnoses without final diagnoses from the submitting institution. Within the remaining 1032 patients, the serious/major discrepancy rate was 4.8%, and less serious and minor discrepancies were seen in 19.4% of the cases. The discrepancy rate was higher among patients who were referred to NCCN institutions for consultation compared to those who were referred for treatment only. The discrepancy rates, patient demographics, type of consultations and submitting institutions varied among participating NCCN institutions. Expert consultations identified a subset of cases with significant diagnostic discrepancies, and constituted the initial diagnoses in some cases. These data indicate that expert consultations in glial tumors and all types of pediatric CNS tumors can improve accurate diagnosis and enable appropriate management.

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Published In

J Neuropathol Exp Neurol

DOI

EISSN

1554-6578

Publication Date

March 1, 2017

Volume

76

Issue

3

Start / End Page

189 / 194

Location

England

Related Subject Headings

  • Pathologists
  • Neuropathology
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Central Nervous System Neoplasms
  • Cancer Care Facilities
  • Adult
 

Citation

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Chicago
ICMJE
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Bruner, J. M., Louis, D. N., McLendon, R., Rosenblum, M. K., Archambault, W. T., Most, S., & Tihan, T. (2017). The Utility of Expert Diagnosis in Surgical Neuropathology: Analysis of Consultations Reviewed at 5 National Comprehensive Cancer Network Institutions. J Neuropathol Exp Neurol, 76(3), 189–194. https://doi.org/10.1093/jnen/nlw122
Bruner, Janet M., David N. Louis, Roger McLendon, Marc K. Rosenblum, W Tad Archambault, Susan Most, and Tarik Tihan. “The Utility of Expert Diagnosis in Surgical Neuropathology: Analysis of Consultations Reviewed at 5 National Comprehensive Cancer Network Institutions.J Neuropathol Exp Neurol 76, no. 3 (March 1, 2017): 189–94. https://doi.org/10.1093/jnen/nlw122.
Bruner JM, Louis DN, McLendon R, Rosenblum MK, Archambault WT, Most S, et al. The Utility of Expert Diagnosis in Surgical Neuropathology: Analysis of Consultations Reviewed at 5 National Comprehensive Cancer Network Institutions. J Neuropathol Exp Neurol. 2017 Mar 1;76(3):189–94.
Bruner, Janet M., et al. “The Utility of Expert Diagnosis in Surgical Neuropathology: Analysis of Consultations Reviewed at 5 National Comprehensive Cancer Network Institutions.J Neuropathol Exp Neurol, vol. 76, no. 3, Mar. 2017, pp. 189–94. Pubmed, doi:10.1093/jnen/nlw122.
Bruner JM, Louis DN, McLendon R, Rosenblum MK, Archambault WT, Most S, Tihan T. The Utility of Expert Diagnosis in Surgical Neuropathology: Analysis of Consultations Reviewed at 5 National Comprehensive Cancer Network Institutions. J Neuropathol Exp Neurol. 2017 Mar 1;76(3):189–194.
Journal cover image

Published In

J Neuropathol Exp Neurol

DOI

EISSN

1554-6578

Publication Date

March 1, 2017

Volume

76

Issue

3

Start / End Page

189 / 194

Location

England

Related Subject Headings

  • Pathologists
  • Neuropathology
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Central Nervous System Neoplasms
  • Cancer Care Facilities
  • Adult